Pregled bibliografske jedinice broj: 1195901
Thieno[2,3-b]Pyridine Derivative Targets Epithelial, Mesenchymal and Hybrid CD15s+ Breast Cancer Cells
Thieno[2,3-b]Pyridine Derivative Targets Epithelial, Mesenchymal and Hybrid CD15s+ Breast Cancer Cells // Medicines (Basel), 8 (2021), 7; 32, 12 doi:10.3390/medicines8070032 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1195901 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Thieno[2,3-b]Pyridine Derivative Targets Epithelial,
Mesenchymal and Hybrid CD15s+ Breast Cancer Cells
Autori
Marijan, Sandra* ; Mastelić, Angela* ; Markotić, Anita ; Režić-Mužinić, Nikolina ; Vučenović, Nikolina ; Barker, David ; Pilkington, Lisa I. ; Reynisson, Jóhannes ; Čulić, Vedrana Čikeš
Izvornik
Medicines (Basel) (2305-6320) 8
(2021), 7;
32, 12
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
triple-negative breast cancer, thieno[2, 3-b]pyridine, CD15s glycosphingolipid, CD15s glycoprotein, CD44, CD24
Sažetak
The adhesion of cancer cells to vascular endothelium is a critical process in hematogenous metastasis and might be similar to the recruitment of leukocytes at the site of inflammation. It is mediated by E-selectin and its ligands, of which the most stereospecific is a glycoconjugate sialyl Lewis x (CD15s), which may be expressed as an oligosaccharide branch of the CD44 glycoprotein, as well as a self-contained glycosphingolipid. It is also known that increased sialylation of glycoconjugates is a feature of malignant cells. The aim of the study was to analyse the effect of a novel thieno[2, 3-b]pyridine, compound 1, in MDA- MB-231 triple-negative breast cancer cells (TNBCs) upon CD15s and CD44 expression in different cell subpopulations using flow cytometry. CD15s expression was compared between mesenchymal-like cancer stem cells (CSC, CD44+CD24−), epithelial cells without CD44 (CD44−CD24+ and CD44−CD24−), and CD44+CD24+ cells that exhibit mesenchymal and epithelial features. In addition, expression of CD44 in CD15s+CSC and CD15s−CSC was determined. Compound 1 significantly decreased the percentage of CD15s+CSC, CD15s+CD44+CD24+, and CD15s+CD44− subpopulations, as well as the expression of CD15s in CD44+CD24+ and CD44− cells, and therefore shows potential as a treatment for TNBC.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Split
Profili:
Sandra Marijan
(autor)
Anita Markotić
(autor)
Angela Mastelić
(autor)
Nikolina Režić Mužinić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- MEDLINE