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Pregled bibliografske jedinice broj: 1195901

Thieno[2,3-b]Pyridine Derivative Targets Epithelial, Mesenchymal and Hybrid CD15s+ Breast Cancer Cells


Marijan, Sandra*; Mastelić, Angela*; Markotić, Anita; Režić-Mužinić, Nikolina; Vučenović, Nikolina; Barker, David; Pilkington, Lisa I.; Reynisson, Jóhannes; Čulić, Vedrana Čikeš
Thieno[2,3-b]Pyridine Derivative Targets Epithelial, Mesenchymal and Hybrid CD15s+ Breast Cancer Cells // Medicines (Basel), 8 (2021), 7; 32, 12 doi:10.3390/medicines8070032 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1195901 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Thieno[2,3-b]Pyridine Derivative Targets Epithelial, Mesenchymal and Hybrid CD15s+ Breast Cancer Cells

Autori
Marijan, Sandra* ; Mastelić, Angela* ; Markotić, Anita ; Režić-Mužinić, Nikolina ; Vučenović, Nikolina ; Barker, David ; Pilkington, Lisa I. ; Reynisson, Jóhannes ; Čulić, Vedrana Čikeš

Izvornik
Medicines (Basel) (2305-6320) 8 (2021), 7; 32, 12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
triple-negative breast cancer, thieno[2, 3-b]pyridine, CD15s glycosphingolipid, CD15s glycoprotein, CD44, CD24

Sažetak
The adhesion of cancer cells to vascular endothelium is a critical process in hematogenous metastasis and might be similar to the recruitment of leukocytes at the site of inflammation. It is mediated by E-selectin and its ligands, of which the most stereospecific is a glycoconjugate sialyl Lewis x (CD15s), which may be expressed as an oligosaccharide branch of the CD44 glycoprotein, as well as a self-contained glycosphingolipid. It is also known that increased sialylation of glycoconjugates is a feature of malignant cells. The aim of the study was to analyse the effect of a novel thieno[2, 3-b]pyridine, compound 1, in MDA- MB-231 triple-negative breast cancer cells (TNBCs) upon CD15s and CD44 expression in different cell subpopulations using flow cytometry. CD15s expression was compared between mesenchymal-like cancer stem cells (CSC, CD44+CD24−), epithelial cells without CD44 (CD44−CD24+ and CD44−CD24−), and CD44+CD24+ cells that exhibit mesenchymal and epithelial features. In addition, expression of CD44 in CD15s+CSC and CD15s−CSC was determined. Compound 1 significantly decreased the percentage of CD15s+CSC, CD15s+CD44+CD24+, and CD15s+CD44− subpopulations, as well as the expression of CD15s in CD44+CD24+ and CD44− cells, and therefore shows potential as a treatment for TNBC.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Split

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Marijan, Sandra*; Mastelić, Angela*; Markotić, Anita; Režić-Mužinić, Nikolina; Vučenović, Nikolina; Barker, David; Pilkington, Lisa I.; Reynisson, Jóhannes; Čulić, Vedrana Čikeš
Thieno[2,3-b]Pyridine Derivative Targets Epithelial, Mesenchymal and Hybrid CD15s+ Breast Cancer Cells // Medicines (Basel), 8 (2021), 7; 32, 12 doi:10.3390/medicines8070032 (međunarodna recenzija, članak, znanstveni)
Marijan, S., Mastelić, A., Markotić, A., Režić-Mužinić, N., Vučenović, N., Barker, D., Pilkington, L., Reynisson, J. & Čulić, V. (2021) Thieno[2,3-b]Pyridine Derivative Targets Epithelial, Mesenchymal and Hybrid CD15s+ Breast Cancer Cells. Medicines (Basel), 8 (7), 32, 12 doi:10.3390/medicines8070032.
@article{article, author = {Marijan, Sandra\ast and Masteli\'{c}, Angela\ast and Markoti\'{c}, Anita and Re\v{z}i\'{c}-Mu\v{z}ini\'{c}, Nikolina and Vu\v{c}enovi\'{c}, Nikolina and Barker, David and Pilkington, Lisa I. and Reynisson, J\'{o}hannes and \v{C}uli\'{c}, Vedrana \v{C}ike\v{s}}, year = {2021}, pages = {12}, DOI = {10.3390/medicines8070032}, chapter = {32}, keywords = {triple-negative breast cancer, thieno[2, 3-b]pyridine, CD15s glycosphingolipid, CD15s glycoprotein, CD44, CD24}, journal = {Medicines (Basel)}, doi = {10.3390/medicines8070032}, volume = {8}, number = {7}, issn = {2305-6320}, title = {Thieno[2,3-b]Pyridine Derivative Targets Epithelial, Mesenchymal and Hybrid CD15s+ Breast Cancer Cells}, keyword = {triple-negative breast cancer, thieno[2, 3-b]pyridine, CD15s glycosphingolipid, CD15s glycoprotein, CD44, CD24}, chapternumber = {32} }
@article{article, author = {Marijan, Sandra\ast and Masteli\'{c}, Angela\ast and Markoti\'{c}, Anita and Re\v{z}i\'{c}-Mu\v{z}ini\'{c}, Nikolina and Vu\v{c}enovi\'{c}, Nikolina and Barker, David and Pilkington, Lisa I. and Reynisson, J\'{o}hannes and \v{C}uli\'{c}, Vedrana \v{C}ike\v{s}}, year = {2021}, pages = {12}, DOI = {10.3390/medicines8070032}, chapter = {32}, keywords = {triple-negative breast cancer, thieno[2, 3-b]pyridine, CD15s glycosphingolipid, CD15s glycoprotein, CD44, CD24}, journal = {Medicines (Basel)}, doi = {10.3390/medicines8070032}, volume = {8}, number = {7}, issn = {2305-6320}, title = {Thieno[2,3-b]Pyridine Derivative Targets Epithelial, Mesenchymal and Hybrid CD15s+ Breast Cancer Cells}, keyword = {triple-negative breast cancer, thieno[2, 3-b]pyridine, CD15s glycosphingolipid, CD15s glycoprotein, CD44, CD24}, chapternumber = {32} }

Časopis indeksira:


  • MEDLINE


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