Naslov
In situ gelling nanosuspension as an advanced platform for fluticasone propionate nasal delivery

Autori
Nižić Nodilo, Laura ; Perkušić, Mirna ; Ugrina, Ivo ; Špoljarić, Drago ; Jakobušić Brala, Cvijeta ; Amidžić Klarić, Daniela ; Lovrić, Jasmina ; Saršon, Vesna ; Safundžić Kučuk, Maša ; Zadravec, Dijana ; Kalogjera, Livije ; Pepić, Ivan ; Hafner, Anita

Izvornik
European journal of pharmaceutics and biopharmaceutics (0939-6411) 175 (2022); 27-42

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
in situ gelling ; nanosuspension ; fluticasone propionate ; nasal drug delivery ; 3D printed nasal cavity model ; chronic rhinosinusitis

Sažetak
In this work we present the development of in situ gelling nanosuspension as an advanced form for fluticasone propionate nasal delivery. Drug nanocrystals were prepared by wet milling technique. Incorporation of drug nanocrystals into polymeric in situ gelling system with pectin and sodium hyaluronate as constitutive polymers was fine-tuned attaining appropriate formulation surface tension, viscosity and gelling ability. Drug nanonisation improved the release profile and enhanced formulation mucoadhesive properties. QbD approach combining formulation and administration parameters resulted in optimised nasal deposition profile, with 51.8% of the dose deposited in the middle meatus, the critical region in the treatment of rhinosinusitis and nasal polyposis. Results obtained in biocompatibility and physico- chemical stability studies confirmed the leading formulation potential for safe and efficient nasal corticosteroid delivery.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA