Naslov
Physical symptoms, degree of anxiety and depression correlate with the concentration of HSP70 in the saliva of patients with rheumatoid arthritis

Autori
Rogoznica, Marija ; Laškarin, Ana-Marija ; Drvar, Verdrana ; Peršić, Viktor ; Kehler, Tatjana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts 1st Biomedicine and Health PhD Students Congress with International Participation "Science and Us" / Šutić Udović, Ingrid ; Knežević, Maša ; Viduka, Ina - Rijeka : Medicinski fakultet Sveučilišta u Rijeci, 2022, 89-90

Skup
1st Biomedicine and Health PhD Students Congress “Science and Us”

Mjesto i datum
Rijeka, Hrvatska, 19.05.2022. - 20.05.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
anxiety ; depression ; heat shock protein ; pain ; rheumatoid arthritis

Sažetak
Anxiety and depression are common in patients with chronic pain, which may appear in patients with rheumatoid arthritis (RA) despite treatment. Pain is usually the most pronounced symptom in patients with active RA, which is mediated by proinflammatory substances originating from immune cells that inhabit the tissues of the joint. Pain represents stress for the body. Hsps are a class of stress-inducible proteins that mainly act as molecular protein chaperones with the aim to protect the cell. However, their excessive production, leaking from damaged or necrotic cells contributes to inflammation and pain signaling. There is clinical evidence for elevation of disease associated molecular pattern signaling in major depressive disorder in patients and in pre- clinical animal stress models of depression. The aim of our study was to investigate the corelation of salivary HSP70 and parameters of RA activity including depressive disorder and anxiety. Patients (53) diagnosed with RA in the rheumatology office of the Hospital „Thalassotherapia-Opatija“ were enroled in this study. They were treated according to the recommendations of the Croatian and European Rheumatological Society. RA activity was measured by number of sore and/or swollen joints, visual analog scale (VAS) for pain (1-100/100 mm), duration of morning stiffness (min), erythrocyte sedimentation rate (mm), and C-reactive protein (CRP, mg/L). We assessed the degree of anxiety disorder with the GAD-7 questionnaire, depressed mood with the PHQ-9 questionnaire, and the physical health symptoms of patients with the PHQ- 15 questionnaire. Pain was the dominant symptom in patients with RA, indispensible of the number of sore or swollen joints and the duration of morning stiffness. The concentration of HSP70 in the saliva of patients with RA correlated with general physical symptoms, but also with the degree of depression and anxiety disorder. However, HSP70 did not correlate with the routine clinical and laboratory indicators of RA activity, mentiioned above. The concentration of HSP70 in the saliva of patients may indicate the development of depressive and anxiety disorders, general physical symptoms, in patients with RA.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Dentalna medicina

POVEZANOST RADA