Pregled bibliografske jedinice broj: 1195656
The Importance of Glycosylation in COVID-19 Infection
The Importance of Glycosylation in COVID-19 Infection // The Role of Glycosylation in Health and Disease / Lauc, Gordan ; Trbojević-Akmačić, Irena (ur.).
Cham: Springer, 2021. str. 239-264 doi:10.1007/978-3-030-70115-4_12
CROSBI ID: 1195656 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
The Importance of Glycosylation in COVID-19
Infection
Autori
Petrović, Tea ; Lauc, Gordan ; Trbojević-Akmačić, Irena
Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, pregledni
Knjiga
The Role of Glycosylation in Health and Disease
Urednik/ci
Lauc, Gordan ; Trbojević-Akmačić, Irena
Izdavač
Springer
Grad
Cham
Godina
2021
Raspon stranica
239-264
ISBN
978-3-030-70115-4
Ključne riječi
COVID-19 ; glycosylation ; SARS-CoV-2 ; S glycoprotein ; viral infection
Sažetak
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2), is currently one of the major health problems worldwide. SARS-CoV-2 survival and virulence are shown to be impacted by glycans, covalently attached to proteins in a process of glycosylation, making glycans an area of interest in SARS-CoV-2 biology and COVID-19 infection. The SARS-CoV-2 uses its highly glycosylated spike (S) glycoproteins to bind to the cell surface receptor angiotensin-converting enzyme 2 (ACE2) glycoprotein and facilitate host cell entry. Viral glycosylation has wide-ranging roles in viral pathobiology, including mediating protein folding and stability, immune evasion, host receptor attachment, and cell entry. Modification of SARS- CoV-2 envelope membrane with glycans is important in host immune recognition and interaction between S and ACE2 glycoproteins. On the other hand, immunoglobulin G, a key molecule in immune response, shows a distinct glycosylation profile in COVID-19 infection and with increased disease severity. Hence, further studies on the role of glycosylation in SARS-CoV-2 infectivity and COVID- 19 infection are needed for its successful prevention and treatment. This chapter focuses on recent findings on the importance of glycosylation in COVID-19 infection.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija, Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
POVEZANOST RADA
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
GENOS d.o.o.
