Naslov
Clinical implications for cannabinoid use in the rheumatic diseases: Potential for help or harm?

Autori
Fitzcharles, Mary-Ann ; McDougall, Jason ; Ste- Marie, Peter A. ; Padjen, Ivan

Izvornik
Arthritis & Rheumatism (0004-3591) 64 (2012), 8; 2417-2425

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
cannabinoids ; rheumatic diseases

Sažetak
Although use of cannabinoids and a clear understanding of the endocannabinoid system may be pertinent to the mechanisms and management of the rheumatic diseases, there remains limited evidence to support the therapeutic use of cannabinoids to date, and unanswered questions remain with regard to their true clinical efficacy and long-term risks. The ubiquitous distribution of cannabinoid receptors throughout the body, coupled with the known effects of cannabinoids on inflammation, pain, and even joint damage, should prompt further study in the rheumatic diseases. Indeed, preclinical studies look promising, with future protocols perhaps involving peripherally restricted cannabinoids or agents that boost endocannabinoid tone.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA