Naslov
Ochratoxin A potentiates citrinin accumulation in kidney and liver of rats

Autori
Rašić, Dubravka ; Stefanović, Srđan ; Milićević, Dragan ; Mladinić, Marin ; Želježić, Davor ; Pizent, Alica ; Konjevoda, Paško ; Peraica, Maja

Izvornik
Arhiv za higijenu rada i toksikologiju (0004-1254) 73 (2022), 1; 43-47

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
experimental rats ; mycotoxins ; organic anion transporters ; resveratrol ; toxicity

Sažetak
Ochratoxin A (OTA) and citrinin (CTN) are nephrotoxic mycotoxins often found together in grain. The aim of this study was to measure their accumulation in the kidney and liver of adult male Wistar rats, see how it would be affected by combined treatment, and to determine if resveratrol (RSV) would decrease their levels in these organs. The rats received 125 or 250 mg/kg bw of OTA by gavage every day for 21 days and/or 20 mg/kg bw of CTN a day for two days. Two groups of rats treated with OTA+CTN were also receiving 20 mg/kg bw of RSV a day for 21 days. In animals receiving OTA alone, its accumulation in both organs was dose-dependent. OTA+CTN treatment resulted in lower OTA but higher CTN accumulation in both organs at both OTA doses. RSV treatment increased OTA levels in the kidney and liver and decreased CTN levels in the kidney. Our findings point to the competition between CTN and OTA for organic anion transporters 1 and 3.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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