Pregled bibliografske jedinice broj: 1195065
AN ECO-FRIENDLY SYNTHESIS OF NOVEL 2-ARYL BENZOXAZOLE DERIVATIVES
AN ECO-FRIENDLY SYNTHESIS OF NOVEL 2-ARYL BENZOXAZOLE DERIVATIVES // 8th International Conference on New Trends in Chemistry
Famagusta, Cipar, 2022. str. 1-2 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 1195065 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
AN ECO-FRIENDLY SYNTHESIS OF NOVEL 2-ARYL
BENZOXAZOLE DERIVATIVES
Autori
Rakas, Anja ; Raić-Malić, Silvana ; Gazivoda Kraljević, Tatjana
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Skup
8th International Conference on New Trends in Chemistry
Mjesto i datum
Famagusta, Cipar, 15.05.2022. - 18.05.2022
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
benzoxazoles, green chemistry, deep eutectic solvent, mechanochemical synthesis, solvent-free synthesis
Sažetak
The benzoxazole heterocycle is often found in ligands targeting a plethora of receptors and enzymes. Furthermore, bioavailability, metabolism and the use of benzoxazole as bioisostere are discussed. The development of new reaction media plays a key-role within the green chemistry framework [1]. The goal of obtaining novel media with low environmental impact represents, in fact, a challenge in modern chemistry, considering the toxicity and the high vapour pressure of traditional organic solvents [2]. Deep eutectic solvents (DES) have important physico-chemical advantages in terms of “greenness” compared to typical organic solvents. Moreover, DESs made of urea, glycerol, water or choline chloride are particularly promising in synthesis from green chemistry point of view because of their low cost and environment-friendliness [3]. The main aim of research is synthesis of novel 2-arylbenzoxazole derivatives by using modern synthetic green approach including mechanochemical and microwave reactions as well as application of different DES. The key precursors of 4-O-alkylated benzaldehyde for the synthesis of target benzoxazole derivatives were prepared in DES (ChCl/glycerol) with K2CO3 as a base. Schiff bases were performed by mechanochemical reactions of 4-O-alkylated benzaldehyde with 2-aminophenole in a ball mills. 2-arylbenzoxazole derivatives were synthesized by microwave assisted cyclization reaction of Schiff bases with NaCN in ethanol.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
HRZZ-IP-2018-01-4682 - Novi spojevi temeljeni na bioizosterima purina za ispitivanje njihovih antitumorskih i antipatogenih djelovanja (PurBioCaPa) (Raić-Malić, Silvana, HRZZ - 2018-01) ( CroRIS)
Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb
