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Pregled bibliografske jedinice broj: 1194868

Reversal of delayed vasospasm by an inhibitor of the synthesis of 20-HETE


Takeuchi, Kazuhiko; Renic, Marija; Bohman, Quinn C; Harder, David R; Miyate, Noriyuki; Roman, Richard J
Reversal of delayed vasospasm by an inhibitor of the synthesis of 20-HETE // Am J Physiol Heart Circ Physiol, 289 (2005), H2203-H2211 doi:10.1152/ajpheart.00556.2005 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1194868 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Reversal of delayed vasospasm by an inhibitor of the synthesis of 20-HETE

Autori
Takeuchi, Kazuhiko ; Renic, Marija ; Bohman, Quinn C ; Harder, David R ; Miyate, Noriyuki ; Roman, Richard J

Izvornik
Am J Physiol Heart Circ Physiol (0363-6135) 289 (2005); H2203-H2211

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
subarachnoid hemorrhage ; 20-hydroxyeicosatetraenoic acid ; cerebral injury

Sažetak
This study characterized the time course of changes in cerebral blood flow (CBF) and vascular diameter in a dual-hemorrhage model of subarachnoid hemorrhage (SAH) in rats and examined whether acute blockade of the synthesis of 20- hydroxyeicosatetraenoic acid (20-HETE) with N-(3- chloro-4-morpholin-4-yl)phenyl-N- hydroxyimido formamide (TS- 011) can reverse delayed vasospasm in this model. Rats received an intracisternal injection of blood (0.4 ml) on day 0 and a second injection 2 days later. CBF was sequentially measured using laser- Doppler flowmetry, and the diameters of the cerebral arteries were determined after filling the cerebral vasculature with a casting compound. CBF fell to 67% of control after the first intracisternal injection of blood but returned to a value near control 24 h later. CBF again fell to 63% of control after a second intracisternal injection of blood and remained 30% below control for 5 days. The fall in CBF after the second intracisternal injection of blood was associated with a sustained 30% reduction in the diameters of the middle cerebral, posterior communicating, and basilar arteries. Acute blockade of the synthesis of 20-HETE with TS-011 (0.1 mg/kg iv), 5 days after the second SAH, increased the diameters of the cerebral arteries, and CBF returned to control. These results indicate that the rats develop delayed vasospasm after induction of the dual-hemorrhage model of SAH and that blockade of the synthesis of 20-HETE fully reverses cerebral vasospasm in this model. They also implicate 20- HETE in the development and maintenance of delayed cerebral vasospasm.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Profili:

Avatar Url Marija Renić (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Takeuchi, Kazuhiko; Renic, Marija; Bohman, Quinn C; Harder, David R; Miyate, Noriyuki; Roman, Richard J
Reversal of delayed vasospasm by an inhibitor of the synthesis of 20-HETE // Am J Physiol Heart Circ Physiol, 289 (2005), H2203-H2211 doi:10.1152/ajpheart.00556.2005 (međunarodna recenzija, članak, znanstveni)
Takeuchi, K., Renic, M., Bohman, Q., Harder, D., Miyate, N. & Roman, R. (2005) Reversal of delayed vasospasm by an inhibitor of the synthesis of 20-HETE. Am J Physiol Heart Circ Physiol, 289, H2203-H2211 doi:10.1152/ajpheart.00556.2005.
@article{article, author = {Takeuchi, Kazuhiko and Renic, Marija and Bohman, Quinn C and Harder, David R and Miyate, Noriyuki and Roman, Richard J}, year = {2005}, pages = {H2203-H2211}, DOI = {10.1152/ajpheart.00556.2005}, keywords = {subarachnoid hemorrhage, 20-hydroxyeicosatetraenoic acid, cerebral injury}, journal = {Am J Physiol Heart Circ Physiol}, doi = {10.1152/ajpheart.00556.2005}, volume = {289}, issn = {0363-6135}, title = {Reversal of delayed vasospasm by an inhibitor of the synthesis of 20-HETE}, keyword = {subarachnoid hemorrhage, 20-hydroxyeicosatetraenoic acid, cerebral injury} }
@article{article, author = {Takeuchi, Kazuhiko and Renic, Marija and Bohman, Quinn C and Harder, David R and Miyate, Noriyuki and Roman, Richard J}, year = {2005}, pages = {H2203-H2211}, DOI = {10.1152/ajpheart.00556.2005}, keywords = {subarachnoid hemorrhage, 20-hydroxyeicosatetraenoic acid, cerebral injury}, journal = {Am J Physiol Heart Circ Physiol}, doi = {10.1152/ajpheart.00556.2005}, volume = {289}, issn = {0363-6135}, title = {Reversal of delayed vasospasm by an inhibitor of the synthesis of 20-HETE}, keyword = {subarachnoid hemorrhage, 20-hydroxyeicosatetraenoic acid, cerebral injury} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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