Naslov
Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction

Autori
Vukičević, Slobodan ; Colliva, Andrea ; Kufner, Vera ; Martinelli, Valentina ; Moimas, Silvia ; Vodret, Simone ; Rumenović, Viktorija ; Milošević, Milan ; Brkljačić, Boris ; Delić-Brkljačić, Diana ; Correa, Ricardo ; Giacca, Mauro ; Maglione, Manuel ; Bordukalo Nikšić, Tatjana ; Dumić-Čule, Ivo ; Zacchigna, Serena

Izvornik
Nature communications (2041-1723) 13 (2022), 1; 81, 11

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
BMP1.3 ; antibody ; ishemic heart disease ; collagen

Sažetak
Despite the high prevalence of ischemic heart diseases worldwide, no antibody-based treatment currently exists. Starting from the evidence that a specific isoform of the Bone Morphogenetic Protein 1 (BMP1.3) is particularly elevated in both patients and animal models of myocardial infarction, here we assess whether its inhibition by a specific monoclonal antibody reduces cardiac fibrosis. We find that this treatment reduces collagen deposition and cross-linking, paralleled by enhanced cardiomyocyte survival, both in vivo and in primary cultures of cardiac cells. Mechanistically, we show that the anti-BMP1.3 monoclonal antibody inhibits Transforming Growth Factor β pathway, thus reducing myofibroblast activation and inducing cardioprotection through BMP5. Collectively, these data support the therapeutic use of anti-BMP1.3 antibodies to prevent cardiomyocyte apoptosis, reduce collagen deposition and preserve cardiac function after ischemia.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA