Pregled bibliografske jedinice broj: 1194536
Mixed Adjuvant Formulation Based on Peptide Hydrogel and Desmuramyl Peptides: Preparation and Influence on Specific Immune Reaction
Mixed Adjuvant Formulation Based on Peptide Hydrogel and Desmuramyl Peptides: Preparation and Influence on Specific Immune Reaction // FEBS Open Bio, Vol. 11, Suppl 1 : 45th FEBS Congress, Molecules of Life: Towards New Horizons
Ljubljana, Slovenija, 2021. str. 296-296 doi:10.1002/2211-5463.13205 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 1194536 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Mixed Adjuvant Formulation Based on Peptide
Hydrogel and Desmuramyl Peptides: Preparation and
Influence on Specific Immune Reaction
Autori
Frkanec, Ruža ; Jakopin, Žiga ; Guzelj, Samo ; Gazdek, Nika ; Štimac, Adela ; Frkanec, Leo
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
FEBS Open Bio, Vol. 11, Suppl 1 : 45th FEBS Congress, Molecules of Life: Towards New Horizons
/ - , 2021, 296-296
Skup
45th FEBS Congress: Molecules of Life: Towards New Horizons (FEBS 2021)
Mjesto i datum
Ljubljana, Slovenija, 03.07.2021. - 08.07.2021
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Adjuvant ; peptide hydrogel ; Desmuramyl peptide ; immune reaction ;
Sažetak
Adjuvants are essential for enhancing vaccine potency by improvement of the humoral and cell mediated immune response to vaccine antigens. Adjuvants of new generation are adjuvant systems composed of various combinations of classical adjuvants designed to adjust the adaptive immune responses against pathogens. The challenge for this strategy is to define an effective and safe formulation in which individual components can synergize with one another to elicit a more robust immune response. Selfassembling peptides have a great potential for applications in bionanotechnology and it has been shown that certain peptides possess immunostimulatory activity (1). Muramyl dipeptide (MDP) is a synthetic immunoactive peptide consisting of N acetyl muramic acid attached to a dipeptide LAlaD isoGln. It was first identified in bacterial cell wall peptidoglycan as the smallest fragment possessing adjuvant activity. Desmuramylpeptides have been extensively studied in an attempt to increase adjuvant activity and boost the immune response effectively for clinical use in the treatment of cancer and other diseases. We report here the preparation and characterization of adjuvant system based on supramolecular hydrogel of a selfassembling tripeptide AcLPheLPheLAlaNH2 with builtin desmuramylpeptide immunopotentiators (2, 3). Recently, a series of novel acyl tripeptides mimicking MDP were identified as potent nanomolar NOD2 agonists. The most potent derivatives were incorporated into hydrogel and tested in the mouse model of adjuvancy. The obtained results show that adjuvant system based on a hydrogel of a selfassembling tripeptide AcL PheLPheLAlaNH2 with builtin desmuramylpeptides elicits stronger specific immune response in comparison with antigen and adjuvant alone.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biotehnologija
POVEZANOST RADA
Projekti:
HRZZ-IP-2018-01-6910 - Sinteza supramolekulskih samo-udruženih nanostruktura za izgradnju naprednih funkcionalnih materijala (SUPeRNANO) (Frkanec, Leo, HRZZ - 2018-01) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Sveučilište u Zagrebu
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE