Naslov
Arterial Hypertension and Risk of Mortality in Patients with COVID-19 Infection

Autori
Bukal, Nikolina ; Kolarić, Melanija ; Golubić, Ines ; Josipović, Josipa ; Premužić, Vedran ; Jelakovic, Ana ; Karanović, Sandra ; Bašić Jukić, Nikolina ; Jelaković, Bojan

Izvornik
Southeastern European medical journal (2459-9484) 6 (2022), 1; 74-82

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
arterial hypertension ; COVID-19 infection ; renin-angiotensin system

Sažetak
COVID-19 is currently a major global health concern. Among many unanswered questions related to COVID-19, some of the most debated ones are those concerning arterial hypertension. Arterial hypertension is a major risk factor for mortality worldwide and its importance has been emphasised even further in light of COVID-19. The most common antihypertensive drugs are ACE inhibitors and angiotensin II type-I receptor blockers. SARS-CoV- 2 utilises the angiotensin- converting enzyme-2 (ACE2) for cell entry and therefore has a direct effect on the renin– angiotensin system (RAS). In terms of arterial hypertension and COVID-19, there are three main issues which have been the focus of extensive debates. First, is arterial hypertension a predisposing factor for COVID-19 infection? Second, does arterial hypertension affect the severity of COVID-19 infection and increase the risk of all-cause and cardiovascular mortality? And finally, how important is the interaction of COVID-19 infection and the renin–angiotensin system for clinical outcomes? Is RAS blockade beneficial or harmful? The aim of this brief review was to provide substantiated answers to these questions.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA