Pregled bibliografske jedinice broj: 1194372
Rijetki slučaj buloznog sindroma Sweet nakon vakcinacije protiv COVID-19
Rijetki slučaj buloznog sindroma Sweet nakon vakcinacije protiv COVID-19 // 7. kongres hrvatskih dermatovenerologa s međunarodnim sudjelovanjem
Vodice, Hrvatska, 2022. (poster, domaća recenzija, neobjavljeni rad, stručni)
CROSBI ID: 1194372 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Rijetki slučaj buloznog sindroma Sweet nakon vakcinacije protiv COVID-19
(A rare case of bullous Sweet syndrome after Covid-19 vaccination)
Autori
Žagar, Tina ; Hlača, Nika ; Skender, Katarina ; Brajac, Ines ; Prpić-Massari, Larisa ; Peternel, Sandra ; Kaštelan, Marija
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, stručni
Skup
7. kongres hrvatskih dermatovenerologa s međunarodnim sudjelovanjem
Mjesto i datum
Vodice, Hrvatska, 05.05.2022. - 08.05.2022
Vrsta sudjelovanja
Poster
Vrsta recenzije
Domaća recenzija
Ključne riječi
adverse reaction ; Sweet syndrome ; COVID-19 vaccine
Sažetak
Concurrent to the increasing use of COVID-19 vaccines, the number of vaccine-related cutaneous and extracutaneous adverse reactions has also increased. Local injection-site reactions are the most reported adverse effects described with the use of these vaccines. A bullous variant of Sweet syndrome (SS) is a rare form of SS, which clinically presents as bullous hemorrhagic rash and demonstrates dermal neutrophilic infiltrates with segregation of dermo-epidermal junction. Only a few cases of SS induced by any vaccine were reported in the literature to our best knowledge. We report a case of a 49-year-old male patient who presented with generalized painful cutaneous eruption. He denied any preceding respiratory or gastrointestinal symptoms or introduction of any medications. However, 10 days before the rash onset, he received the first dose of the SARS- CoV-2 Oxford-AstraZeneca vaccine. Upon physical examination, we observed symmetrically distributed erythematous to violaceous vesicular papules and targetoid plaques on the lower part of the trunk and extremities, along with multiple grouped hemorrhagic blisters on both hands and feet. The patient was subfebrile and reported mild arthralgia, no other extracutaneous symptoms were present. Initial laboratory investigation revealed leukocytosis with neutrophilia, while C-reactive protein, liver, renal function tests, urine analysis were all within the reference range. The SARS-CoV-2 RT-PCR test was negative. IgG SARS-CoV-2 antibodies were positive (895.3 AU/ml). Serology tests for viral and bacterial agents were all negative. Chest X-ray and abdominal ultrasound were unremarkable. Histopathological findings were consistent with Sweet syndrome (SS). Balancing the possible link between vaccination and SS, we decided to contraindicate the second dose of vaccine. Because of the ongoing pandemic and introduction of new vaccines, it is of great importance that all potential side effects are reported and considered.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka,
Sveučilište u Rijeci
Profili:
Larisa Prpić Massari
(autor)
Ines Brajac
(autor)
Marija Kaštelan
(autor)
Nika Hlača
(autor)
Sandra Peternel
(autor)