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Pregled bibliografske jedinice broj: 1194201

Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug

Marschallinger, Julia; Schäffner, Iris; Klein, Barbara; Gelfert, Renate; Rivera, Francisco J.; Illes, Sebastian; Grassner, Lukas; Janssen, Maximilian; Rotheneichner, Peter; Schmuckermair, Claudia et al.
Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug // Nature Communications, 6 (2015), 8466, 16 doi:10.1038/ncomms9466 (međunarodna recenzija, članak, znanstveni)

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Naslov
Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug

Autori
Marschallinger, Julia ; Schäffner, Iris ; Klein, Barbara ; Gelfert, Renate ; Rivera, Francisco J. ; Illes, Sebastian ; Grassner, Lukas ; Janssen, Maximilian ; Rotheneichner, Peter ; Schmuckermair, Claudia ; Coras, Roland ; Boccazzi, Marta ; Chishty, Mansoor ; Lagler, Florian B. ; Renic, Marija ; Bauer, Hans-Christian ; Singewald, Nicolas ; Blümcke, Ingmar ; Bogdahn, Ulrich ; Couillard-Despres, Sebastien ; Lie, D. Chichung ; Abbracchio, Maria P. ; Aigner, Ludwig

Izvornik
Nature Communications (2041-1723) 6 (2015); 8466, 16

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
aging

Sažetak
As human life expectancy has improved rapidly in industrialized societies, age-related cognitive impairment presents an increasing challenge. Targeting histopathological processes that correlate with age-related cognitive declines, such as neuroinflammation, low levels of neurogenesis, disrupted blood–brain barrier and altered neuronal activity, might lead to structural and functional rejuvenation of the aged brain. Here we show that a 6-week treatment of young (4 months) and old (20 months) rats with montelukast, a marketed anti-asthmatic drug antagonizing leukotriene receptors, reduces neuroinflammation, elevates hippocampal neurogenesis and improves learning and memory in old animals. By using gene knockdown and knockout approaches, we demonstrate that the effect is mediated through inhibition of the GPR17 receptor. This work illustrates that inhibition of leukotriene receptor signalling might represent a safe and druggable target to restore cognitive functions in old individuals and paves the way for future clinical translation of leukotriene receptor inhibition for the treatment of dementias.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Marija Renić (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Marschallinger, Julia; Schäffner, Iris; Klein, Barbara; Gelfert, Renate; Rivera, Francisco J.; Illes, Sebastian; Grassner, Lukas; Janssen, Maximilian; Rotheneichner, Peter; Schmuckermair, Claudia et al.
Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug // Nature Communications, 6 (2015), 8466, 16 doi:10.1038/ncomms9466 (međunarodna recenzija, članak, znanstveni)
Marschallinger, J., Schäffner, I., Klein, B., Gelfert, R., Rivera, F., Illes, S., Grassner, L., Janssen, M., Rotheneichner, P. & Schmuckermair, C. (2015) Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug. Nature Communications, 6, 8466, 16 doi:10.1038/ncomms9466.
@article{article, author = {Marschallinger, Julia and Sch\"{a}ffner, Iris and Klein, Barbara and Gelfert, Renate and Rivera, Francisco J. and Illes, Sebastian and Grassner, Lukas and Janssen, Maximilian and Rotheneichner, Peter and Schmuckermair, Claudia and Coras, Roland and Boccazzi, Marta and Chishty, Mansoor and Lagler, Florian B. and Renic, Marija and Bauer, Hans-Christian and Singewald, Nicolas and Bl\"{u}mcke, Ingmar and Bogdahn, Ulrich and Couillard-Despres, Sebastien and Lie, D. Chichung and Abbracchio, Maria P. and Aigner, Ludwig}, year = {2015}, pages = {16}, DOI = {10.1038/ncomms9466}, chapter = {8466}, keywords = {aging}, journal = {Nature Communications}, doi = {10.1038/ncomms9466}, volume = {6}, issn = {2041-1723}, title = {Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug}, keyword = {aging}, chapternumber = {8466} }
@article{article, author = {Marschallinger, Julia and Sch\"{a}ffner, Iris and Klein, Barbara and Gelfert, Renate and Rivera, Francisco J. and Illes, Sebastian and Grassner, Lukas and Janssen, Maximilian and Rotheneichner, Peter and Schmuckermair, Claudia and Coras, Roland and Boccazzi, Marta and Chishty, Mansoor and Lagler, Florian B. and Renic, Marija and Bauer, Hans-Christian and Singewald, Nicolas and Bl\"{u}mcke, Ingmar and Bogdahn, Ulrich and Couillard-Despres, Sebastien and Lie, D. Chichung and Abbracchio, Maria P. and Aigner, Ludwig}, year = {2015}, pages = {16}, DOI = {10.1038/ncomms9466}, chapter = {8466}, keywords = {aging}, journal = {Nature Communications}, doi = {10.1038/ncomms9466}, volume = {6}, issn = {2041-1723}, title = {Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug}, keyword = {aging}, chapternumber = {8466} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

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