Pregled bibliografske jedinice broj: 1193809
Synthesis of 14-membered enediyne-embedded macrocycles
Synthesis of 14-membered enediyne-embedded macrocycles // Organic & biomolecular chemistry, 20 (2022), 18; 3823-3834 doi:10.1039/d2ob00090c (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1193809 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Synthesis of 14-membered enediyne-embedded
macrocycles
Autori
Glavaš, Mladena ; Gredičak, Matija ; Štefanić, Zoran ; Jerić, Ivanka
Izvornik
Organic & biomolecular chemistry (1477-0520) 20
(2022), 18;
3823-3834
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
enediyne structural unit ; macrocycles ; Ugi/Sonogashira reactions
Sažetak
A concise and practical strategy towards a novel class of 14-membered macrocycles containing an enediyne(Z-3-ene-1, 5-diyne) structural unit is described. A highly modular assembly of various precursors via sequential Ugi/Sonogashira reactions allowed the preparation of hybrid enediyne-peptide macrocycles in most cases as single diastereoisomers. Selected macrocyclic compounds showed moderate antiproliferative activity, and can be considered as templates suitable for further diversification in terms of ring size, shape, and stereochemistry.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
HRZZ-IP-2014-09-3102 - Višekomponentne reakcije u sintezi peptidnih mimetika (MIMICRy) (Jerić, Ivanka, HRZZ - 2014-09) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
