Pregled bibliografske jedinice broj: 1193707
New Bicyclic Azalide Macrolides Obtained by Tandem Palladium Catalyzed Allylic Alkylation/Conjugated Addition Reaction
New Bicyclic Azalide Macrolides Obtained by Tandem Palladium Catalyzed Allylic Alkylation/Conjugated Addition Reaction // Molecules, 27 (2022), 2; 432, 14 doi:10.3390/molecules27020432 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1193707 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
New Bicyclic Azalide Macrolides Obtained by Tandem
Palladium Catalyzed Allylic Alkylation/Conjugated
Addition Reaction
Autori
Alihodžić, Sulejman ; Čipčić Paljetak, Hana ; Čikoš, Ana ; Elenkov, Ivaylo Jivkov
Izvornik
Molecules (1420-3049) 27
(2022), 2;
432, 14
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
macrolides ; azalides ; bicyclolides ; tandem reaction ; allylation ; NMR spectroscopy ; conformational analysis
Sažetak
Unprecedented tandem allylic alkylation/intermolecular Michael addition was used in the preparation of novel bicyclic azalides. NMR spectroscopy was used not only to unambiguously determine and characterize the structures of these unexpected products of chemical reaction but also to investigate the effect the rigid bicyclic modification has on the conformation of the whole molecule. Thus, some of the macrolides prepared showed antibacterial activity in the range of well-known antibiotic drug azithromycin.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb
Profili:
Ivaylo Jivkov Elenkov
(autor)
Sulejman Alihodžić
(autor)
Hana Čipčić Paljetak
(autor)
Ana Čikoš
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
