Pregled bibliografske jedinice broj: 1193599
MiRNAs: A potentially valuable tool in pesticide toxicology assessment-current experimental and epidemiological data review
miRNAs: A potentially valuable tool in pesticide toxicology assessment-current experimental and epidemiological data review // Chemosphere, 295 (2022), 133792, 18 doi:10.1016/j.chemosphere.2022.133792 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1193599 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
MiRNAs: A potentially valuable tool in pesticide toxicology
assessment-current experimental and epidemiological data
review
(MiRNAs: A potentially valuable tool in pesticide
toxicology assessment-current experimental and
epidemiological data review)
Autori
Valencia-Quintana, Rafael ; Bahena-Ocampo, Iván Uriel ; González-Castañeda, Gerardo ; Bonilla, Edmundo ; Milić, Mirta ; Bonassi, Stefano ; Sánchez-Alarcón, Juana
Izvornik
Chemosphere (0045-6535) 295
(2022);
133792, 18
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
let-7 ; miR- 9 ; miR-21 ; miR-155 ; miR-181 ; miR-363
Sažetak
MiRNAs are responsible for the regulation of many cellular processes such as development, cell differentiation, proliferation, apoptosis, and tumor growth. Several studies showed that they can also serve as specific, stable, and sensitive markers of chemical exposure. In this review, current experimental and epidemiological data evidencing deregulation in miRNA expression in response to fungicides, insecticides or herbicides were analyzed. As shown by Venn's diagrams, miR- 363 and miR-9 deregulation is associated with fungicide exposure in vitro and in vivo, while let-7, miR-155, miR-181 and miR-21 were found to be commonly deregulated by at least three different insecticides. Furthermore, let-7, miR- 30, miR-126, miR-181 and miR-320 were commonly deregulated by 3 different herbicides. Notably, these 5 miRNAs were also found to be deregulated by one or more insecticides, suggesting their participation in the cellular response to pesticides, regardless of their chemical structure. All these miRNAs have been proposed as potential biomarkers for fungicide, insecticide, or herbicide exposure. These results allow us to improve our understanding of the molecular mechanisms of toxicity upon pesticide exposure, although further studies are needed to confirm these miRNAs as definitive (not potential) biomarkers of pesticide exposure.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Javno zdravstvo i zdravstvena zaštita, Dentalna medicina, Farmacija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
POVEZANOST RADA
Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb
Profili:
Mirta Milić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE