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Pregled bibliografske jedinice broj: 1193446

DNA damage in dementia: Evidence from patients affected by severe Chronic Obstructive Pulmonary Disease (COPD) and meta-analysis of most recent literature


Ilari, Sara; Russo, Patrizia; Proietti, Stefania; Vitiello, Laura; Muscoli, Carolina; Tomino, Carlo; Milic, Mirta; Bonassi, Stefano
DNA damage in dementia: Evidence from patients affected by severe Chronic Obstructive Pulmonary Disease (COPD) and meta-analysis of most recent literature // Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 487 (2022), 503499, 13 doi:10.1016/j.mrgentox.2022.503499 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1193446 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
DNA damage in dementia: Evidence from patients affected by severe Chronic Obstructive Pulmonary Disease (COPD) and meta-analysis of most recent literature

Autori
Ilari, Sara ; Russo, Patrizia ; Proietti, Stefania ; Vitiello, Laura ; Muscoli, Carolina ; Tomino, Carlo ; Milic, Mirta ; Bonassi, Stefano

Izvornik
Mutation Research/Genetic Toxicology and Environmental Mutagenesis (1383-5718) 487 (2022); 503499, 13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
DNA damage ; Chronic Obstructive Pulmonary Disease (COPD) ; Cognitive impairment ; Genomic instability ; Inflammation ; Oxidative stress

Sažetak
Oxidative stress that leads to oxidatively damaged DNA, plays a crucial role in chronic obstructive pulmonary disease (COPD) as well as in the onset of neurodegenerative diseases. The consequent genomic instability is the first neuropathological event found in the preclinical phase of cognitive impairment (CI), and the level of DNA damage is closely related to the degree of dementia. Since CI has been associated with COPD, we investigated the extent of DNA damage in isolated lymphocytes with the Comet assay, in a group of severe COPD patients with cognitive function measured by the Mini-Mental State Examination (MMSE). An increase in DNA damage was observed in COPD patients with dementia (MMSE≤24), although the difference was only borderline (22.4±6.9 vs. 18.5±7.1 ; p = 0.055). Meta-analysis, including the results of the current study, confirmed that patients with MMSE≤24 showed higher level of DNA damage than patients with MMSE>24. We observed a significant reduction (p<0.001) in the MMSE score in patients with cognitive decline in areas I (Orientation), III (Attention and Calculus) and V (Language). Only the temporal orientation category in area I was also associated with the level of oxidative damage, with higher levels of MDA (p<0.01) and DNA damage (p<0.03). Patients with the lowest temporal orientation score had a 12 % higher mean DNA damage (Odds Ratio=1.12 ; 95 % confidence interval (95 %CI) 1.01-1.25 ; p <0.036). Temporal orientation is a component of most screening tests for the diagnosis of cognitive impairment, on the bases that disorientation is a common factor in dementia. Present results show that each component of cognitive decline can have a different etiopathogenesis and clinical relevance. A more thorough assessment of the cognitive functions of patients starting COPD rehabilitation, together with the assessment of DNA and the level of oxidative stress, can provide essential information to adapt and customize the rehabilitation project.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Farmacija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb

Profili:

Avatar Url Mirta Milić (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Ilari, Sara; Russo, Patrizia; Proietti, Stefania; Vitiello, Laura; Muscoli, Carolina; Tomino, Carlo; Milic, Mirta; Bonassi, Stefano
DNA damage in dementia: Evidence from patients affected by severe Chronic Obstructive Pulmonary Disease (COPD) and meta-analysis of most recent literature // Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 487 (2022), 503499, 13 doi:10.1016/j.mrgentox.2022.503499 (međunarodna recenzija, članak, znanstveni)
Ilari, S., Russo, P., Proietti, S., Vitiello, L., Muscoli, C., Tomino, C., Milic, M. & Bonassi, S. (2022) DNA damage in dementia: Evidence from patients affected by severe Chronic Obstructive Pulmonary Disease (COPD) and meta-analysis of most recent literature. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 487, 503499, 13 doi:10.1016/j.mrgentox.2022.503499.
@article{article, author = {Ilari, Sara and Russo, Patrizia and Proietti, Stefania and Vitiello, Laura and Muscoli, Carolina and Tomino, Carlo and Milic, Mirta and Bonassi, Stefano}, year = {2022}, pages = {13}, DOI = {10.1016/j.mrgentox.2022.503499}, chapter = {503499}, keywords = {DNA damage, Chronic Obstructive Pulmonary Disease (COPD), Cognitive impairment, Genomic instability, Inflammation, Oxidative stress}, journal = {Mutation Research/Genetic Toxicology and Environmental Mutagenesis}, doi = {10.1016/j.mrgentox.2022.503499}, volume = {487}, issn = {1383-5718}, title = {DNA damage in dementia: Evidence from patients affected by severe Chronic Obstructive Pulmonary Disease (COPD) and meta-analysis of most recent literature}, keyword = {DNA damage, Chronic Obstructive Pulmonary Disease (COPD), Cognitive impairment, Genomic instability, Inflammation, Oxidative stress}, chapternumber = {503499} }
@article{article, author = {Ilari, Sara and Russo, Patrizia and Proietti, Stefania and Vitiello, Laura and Muscoli, Carolina and Tomino, Carlo and Milic, Mirta and Bonassi, Stefano}, year = {2022}, pages = {13}, DOI = {10.1016/j.mrgentox.2022.503499}, chapter = {503499}, keywords = {DNA damage, Chronic Obstructive Pulmonary Disease (COPD), Cognitive impairment, Genomic instability, Inflammation, Oxidative stress}, journal = {Mutation Research/Genetic Toxicology and Environmental Mutagenesis}, doi = {10.1016/j.mrgentox.2022.503499}, volume = {487}, issn = {1383-5718}, title = {DNA damage in dementia: Evidence from patients affected by severe Chronic Obstructive Pulmonary Disease (COPD) and meta-analysis of most recent literature}, keyword = {DNA damage, Chronic Obstructive Pulmonary Disease (COPD), Cognitive impairment, Genomic instability, Inflammation, Oxidative stress}, chapternumber = {503499} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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