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Pregled bibliografske jedinice broj: 1193315

Variable correlation between bronchoalveolar lavage fluid fungal load and serum-(1,3)-β-d-glucan in patients with pneumocystosis - a multicenter ECMM excellence center study

Mercier, Toine; Aissaoui, Nesrine; Gits-Muselli, Maud; Hamane, Samia; Prattes, Juergen; Kessler, Harald H.; Mareković, Ivana; Pleško, Sanja; Steinmann, Jörg; Scharmann, Ulrike et al.
Variable correlation between bronchoalveolar lavage fluid fungal load and serum-(1,3)-β-d-glucan in patients with pneumocystosis - a multicenter ECMM excellence center study // Journal of fungi, 6 (2020), 4; 327, 8 doi:10.3390/jof6040327 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1193315 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Variable correlation between bronchoalveolar lavage fluid fungal load and serum-(1,3)-β-d-glucan in patients with pneumocystosis - a multicenter ECMM excellence center study
(Variable correlation between bronchoalveolar lavage fluid fungal load and serum-(1,3)-β-d- glucan in patients with pneumocystosis - a multicenter ECMM excellence center study)

Autori
Mercier, Toine ; Aissaoui, Nesrine ; Gits-Muselli, Maud ; Hamane, Samia ; Prattes, Juergen ; Kessler, Harald H. ; Mareković, Ivana ; Pleško, Sanja ; Steinmann, Jörg ; Scharmann, Ulrike ; Maertens, Johan ; Lagrou, Katrien ; Denis, Blandine ; Bretagne, Stéphane ; Alanio, Alexandre

Izvornik
Journal of fungi (2309-608X) 6 (2020), 4; 327, 8

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Pneumocystis jirovecii ; qPCR ; broncho-alveolar lavage fluid ; fungal load ; biomarker ; (1, 3)-β-d-glucan ; non-HIV patient

Sažetak
Abstract: Pneumocystis jirovecii pneumonia is a difficult invasive infection to diagnose. Apart from microscopy of respiratory specimens, two diagnostic tests are increasingly used including real-time quantitative PCR (qPCR) of respiratory specimens, mainly in bronchoalveolar lavage fluids (BAL), and serum β-1, 3-d-glucan (BDG). It is still unclear how these two biomarkers can be used and interpreted in various patient populations. Here we analyzed retrospectively and multicentrically the correlation between BAL qPCR and serum BDG in various patient population, including mainly non-HIV patients. It appeared that a good correlation can be obtained in HIV patients and solid organ transplant recipients but no correlation can be observed in patients with hematologic malignancies, solid cancer, and systemic diseases. This observation reinforces recent data suggesting that BDG is not the best marker of PCP in non-HIV patients, with potential false positives due to other IFI or bacterial infections and false-negatives due to low fungal load and low BDG release.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Sanja Pleško (autor)

Avatar Url Ivana Mareković (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Mercier, Toine; Aissaoui, Nesrine; Gits-Muselli, Maud; Hamane, Samia; Prattes, Juergen; Kessler, Harald H.; Mareković, Ivana; Pleško, Sanja; Steinmann, Jörg; Scharmann, Ulrike et al.
Variable correlation between bronchoalveolar lavage fluid fungal load and serum-(1,3)-β-d-glucan in patients with pneumocystosis - a multicenter ECMM excellence center study // Journal of fungi, 6 (2020), 4; 327, 8 doi:10.3390/jof6040327 (međunarodna recenzija, članak, znanstveni)
Mercier, T., Aissaoui, N., Gits-Muselli, M., Hamane, S., Prattes, J., Kessler, H., Mareković, I., Pleško, S., Steinmann, J. & Scharmann, U. (2020) Variable correlation between bronchoalveolar lavage fluid fungal load and serum-(1,3)-β-d-glucan in patients with pneumocystosis - a multicenter ECMM excellence center study. Journal of fungi, 6 (4), 327, 8 doi:10.3390/jof6040327.
@article{article, author = {Mercier, Toine and Aissaoui, Nesrine and Gits-Muselli, Maud and Hamane, Samia and Prattes, Juergen and Kessler, Harald H. and Marekovi\'{c}, Ivana and Ple\v{s}ko, Sanja and Steinmann, J\"{o}rg and Scharmann, Ulrike and Maertens, Johan and Lagrou, Katrien and Denis, Blandine and Bretagne, St\'{e}phane and Alanio, Alexandre}, year = {2020}, pages = {8}, DOI = {10.3390/jof6040327}, chapter = {327}, keywords = {Pneumocystis jirovecii, qPCR, broncho-alveolar lavage fluid, fungal load, biomarker, (1, 3)-β-d-glucan, non-HIV patient}, journal = {Journal of fungi}, doi = {10.3390/jof6040327}, volume = {6}, number = {4}, issn = {2309-608X}, title = {Variable correlation between bronchoalveolar lavage fluid fungal load and serum-(1,3)-β-d-glucan in patients with pneumocystosis - a multicenter ECMM excellence center study}, keyword = {Pneumocystis jirovecii, qPCR, broncho-alveolar lavage fluid, fungal load, biomarker, (1, 3)-β-d-glucan, non-HIV patient}, chapternumber = {327} }
@article{article, author = {Mercier, Toine and Aissaoui, Nesrine and Gits-Muselli, Maud and Hamane, Samia and Prattes, Juergen and Kessler, Harald H. and Marekovi\'{c}, Ivana and Ple\v{s}ko, Sanja and Steinmann, J\"{o}rg and Scharmann, Ulrike and Maertens, Johan and Lagrou, Katrien and Denis, Blandine and Bretagne, St\'{e}phane and Alanio, Alexandre}, year = {2020}, pages = {8}, DOI = {10.3390/jof6040327}, chapter = {327}, keywords = {Pneumocystis jirovecii, qPCR, broncho-alveolar lavage fluid, fungal load, biomarker, (1, 3)-β-d-glucan, non-HIV patient}, journal = {Journal of fungi}, doi = {10.3390/jof6040327}, volume = {6}, number = {4}, issn = {2309-608X}, title = {Variable correlation between bronchoalveolar lavage fluid fungal load and serum-(1,3)-β-d- glucan in patients with pneumocystosis - a multicenter ECMM excellence center study}, keyword = {Pneumocystis jirovecii, qPCR, broncho-alveolar lavage fluid, fungal load, biomarker, (1, 3)-β-d-glucan, non-HIV patient}, chapternumber = {327} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus

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