Naslov
Vitamin D deficiency in young adults and the question of the need for early replacement for the primary prevention of osteoporosis

Autori
Bačun, Tatjana ; Lekić, Ivan ; Šarić, Jelena ; Bačun, Barbara ; Debeljak, Željko ; Degmečić, Dunja ; Šerić, Vatroslav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, prošireni sažetak, znanstveni

Izvornik
Ece 2021 abstract book / - , 2021, 272-272

Skup
23rd European Congress of Endocrinology (ECE 2021)

Mjesto i datum
Online, 22.05.2021. - 26.05.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
calcifediol ; vitamin D deficiency ; young adults ; liquid chromatography-mass spectrometry ; osteoporosis

Sažetak
Introduction: Low concentrations of vitamin D are associated with decreased calcium absorption, negative calcium balance, and compensatory growth of parathyroid hormone, resulting in excessive bone resorption. The first step in preventing osteoporosis is to ensure a proper diet, especially calcium and vitamin D intake. Aim of the study: The aim of this study was to determine the concentration of 25-hydroxyvitamin D3 (25-OH-D3) in Eastern Croatia in subjects aged 18 to 25 years at the end of winter and to examine whether there is a difference according to gender and compare the results with reference values. Subjects and methods The study was conducted on a sample of 59 subjects, with an average age of 23 years, of which 27 were men (45.8%) and 32 women (54.2%). Blood was drawn and centrifuged at 3.000 rpm for 10 minutes. After centrifugation, serum was collected, and the sample was analyzed by liquid chromatography combined with mass spectrometry (LC-MS/MS). Results: The mean concentration of 25-OH-D3 was 16.36 ng/ml (SD 5.68 ; range 4.90 to 28.60). Men had a statistically significant higher concentration compared to women (18.96 vs. 14.16 ng/ml, p 0.01). The concentration was lower than the reference value (20 to 100 ng/ml). Only 28.8% of subjects (44.4% men and 15.6% women) had values greater than 20 ng/ml. Conclusion: As many as 71.2% of young adults had vitamin D deficiency at the end of the winter period. Women had statistically significant lower concentrations. The observed deficit indicates the need to determine the optimal intake of 25-OH-D3 for the purpose of osteoporosis prevention. It is necessary to conduct research on a larger number of examinees over a longer period with monitoring of outcomes.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA