Pregled bibliografske jedinice broj: 1189946
Impact of positive charge and ring-size on the interactions of calixarenes with DNA, RNA and nucleotides
Impact of positive charge and ring-size on the interactions of calixarenes with DNA, RNA and nucleotides // New journal of chemistry, 46 (2022), 15; 6860-6869 doi:10.1039/D2NJ00061J (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1189946 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Impact of positive charge and ring-size on the
interactions of calixarenes with DNA, RNA and
nucleotides
Autori
Krošl, Ivona, Otković, Ena ; Nikšić-Franjić, Ivana, Colasson, Benoit ; Reinaud, Olivia ; Višnjevac, Aleksandar ; Piantanida, Ivo
Izvornik
New journal of chemistry (1144-0546) 46
(2022), 15;
6860-6869
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
calixarene ; ds-DNA/RNA binding ; nucleotide binding ; fluorescence ; circular dichroism
Sažetak
Comparison of various calix[6]arene and calix[4]arene derivatives revealed that only analogues bearing a permanent positive charge non- covalently bind to ds-DNA and ds-RNA, by insertion into a DNA minor groove or RNA major groove. Also, these cationic analogues revealed strong and highly selective charge-dependent stabilization of AT-DNA against thermal denaturation, the calix[6]arene trication being an order of magnitude more efficient than its calix[4]arene dicationic analogue. At variance to DNA/RNA selectivity for only cationic calixarenes, both neutral and cationic calixarenes bind nucleoside monophosphates with similar efficiency, by forming tweezer-like supramolecular complexes, with nucleobases inserted between aromatic pendant arms grafted to calixarene rims. Such nucleotidecalixarene complexes were monitored by an emission change of calixarene as a function of nucleobase insertion, at variance to DNA/RNA complexes in which calixarene is inserted into the polynucleotide groove, which does not change calixarene emission – stressing the importance of the ligand insertion within a calix-basket for fluorimetric sensing.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti, Biotehnologija
Napomena
Ilustracija iz rada odabrana je za naslovnu stranicu
izdanja NJC (Vol 46, No. 15) u kojem je objavljen.
POVEZANOST RADA
Projekti:
HRZZ-IP-2018-01-5475 - Višekromoforne probe za prepoznavanje pojedinih struktura DNA, RNA i proteina (BioMultiChromoProbes) (Piantanida, Ivo, HRZZ - 2018-01) ( CroRIS)
--IP-2020-02-3786 - Biomimetički “funnel” i “bowl” supramolekularni sustavi za selektivno prepoznavanje DNA/RNA (CALIXDNA / CALIXDNA) (Višnjevac, Aleksandar) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
Profili:
Ivo Piantanida
(autor)
Aleksandar Višnjevac
(autor)
Ivona Krošl Knežević
(autor)
Ivana Nikšić-Franjić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus