Naslov
Rapid clearance of tacrolimus blood concentration triggered by variant pharmacogenes

Autori
Šimičević, Livija ; Canjuga, Iva ; Zibar, Lada ; Borić- Bilušić, Ana ; Ganoci, Lana ; Božina, Nada

Izvornik
Journal of clinical pharmacy and therapeutics (0269-4727) 47 (2022), 9; 1461, 1465

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CYP3A4 ; CYP3A5 ; acute cellular rejection ; case report ; pharmacogenetics ; tacrolimus.

Sažetak
What is known and objective: Tacrolimus (TAC) is an immunosuppressant with large interpatient pharmacokinetic variability and a narrow therapeutic index. We report a case of acute cellular rejection (ACR) type IB with insufficient TAC blood concentrations (TAC C0 ). Case summary: ACR developed on the eighth postoperative day of kidney transplantation. During this period, TAC C0 were insufficient. This referred pharmacogenetic assessment disclosed the patient as a CYP3A5 expresser and CYP3A4*1B carrier. According to the genotype, higher doses of TAC, 15 mg twice daily, were administered and targeted TAC C0 were achieved. What is new and conclusion: Our case presents an association of TAC rapid clearance and two alleles modifying greater CYP3A enzyme activity.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Kliničke medicinske znanosti, Farmacija

POVEZANOST RADA