Naslov
The current concept of prevention and treatment of bone infections - is there anything new

Autori
Sabalic, Srecko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
Prvi kongres ortopeda i traumatologa Crne Gore

Mjesto i datum
Budva, Crna Gora, 26.09.2019. - 28.09.2019

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
bone ; infections ; fractures ; novelty

Sažetak
Periprosthetic joint infection (PJI) is currently the leading cause of failure for primary and revision total knee (TKA) and total hip arthroplasty (THA).As the number of arthroplasties which are performed each year increases, so does the number of patients with PJI, with some predicting an annual rate of between 38000 and 270 000 PJIs in the United States by the year 2030 The management of PJI requires specific resources and carries a heavy financial and psychological burden. Despite extensive research the most effective strategies for prevention of PJI remain unknown. There are several different surgical treatment strategies that are described in this review. Each of these strategies has identical components: (1) de´ bride all infected tissue ; (2) minimize or eliminate the impact of the prosthesis on perpetuating biofilmrelated infection, either by complete resection of the prosthesis or exchange of the removable components ; and (3) maintain sufficient soft tissue coverage to permit healing. One of the most feared and challenging complications in the treatment of musculoskeletal trauma patients is infection after fracture fixation (IAFF), which can delay healing, lead to permanent functional loss, or even amputation of the affected limb. Despite modern advances, implant-related infection remains a problem in fracture care. Much of the surgical and medical treatment concepts currently applied to IAFF have been adopted from prosthetic joint infection (PJI) treatment algorithms. Specific data, tailored towards the musculoskeletal trauma patient, is comparatively scarce. IAFF and PJI do indeed have similar clinical properties, however there are important distinctions between the elective arthroplasty patient and the trauma patient, both in terms of risk of infection at the primary surgery, and in treatment options. Furthermore, we summarize the latest preclinical and clinical research innovations regarding prevention and treatment of PPJI and IAFF.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA