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Pregled bibliografske jedinice broj: 1189107

Thiolated Chitosan Conjugated Liposomes for Oral Delivery of Selenium Nanoparticles

Selmani, Atiđa; Seibert, Elisabeth; Tetyczka, Carolin; Kuehnelt, Doris; Vidaković, Ivan; Kornmueller, Karin; Absenger-Novak, Markus; Radatović, Borna; Vinković Vrček, Ivana; Leitinger, Gerd et al.
Thiolated Chitosan Conjugated Liposomes for Oral Delivery of Selenium Nanoparticles // Pharmaceutics, 14 (2022), 4; 803, 19 doi:10.3390/pharmaceutics14040803 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1189107 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Thiolated Chitosan Conjugated Liposomes for Oral Delivery of Selenium Nanoparticles

Autori
Selmani, Atiđa ; Seibert, Elisabeth ; Tetyczka, Carolin ; Kuehnelt, Doris ; Vidaković, Ivan ; Kornmueller, Karin ; Absenger-Novak, Markus ; Radatović, Borna ; Vinković Vrček, Ivana ; Leitinger, Gerd ; Fröhlich, Eleonore ; Bernkop- Schnürch, Andreas ; Roblegg, Eva ; Prassl, Ruth

Izvornik
Pharmaceutics (1999-4923) 14 (2022), 4; 803, 19

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
thiomers ; microfluidic synthesis ; biophysical characterization ; in vitro intestinal model

Sažetak
This study aimed to design a hybrid oral liposomal delivery system for selenium nanoparticles (Lip- SeNPs) to improve the bioavailability of selenium. Thiolated chitosan, a multifunctional polymer with mucoadhesive properties, was used for surface functionalization of Lip-SeNPs. Selenium nanoparticle (SeNP)-loaded liposomes were manufactured by a single step microfluidics- assisted chemical reduction and assembling process. Subsequently, chitosan-N-acetylcysteine was covalently conjugated to the preformed Lip- SeNPs. The Lip-SeNPs were characterized in terms of composition, morphology, size, zeta potential, lipid organization, loading efficiency and radical scavenging activity. A co-culture system (Caco- 2:HT29-MTX) that integrates mucus secreting and enterocyte-like cell types was used as a model of the human intestinal epithelium to determine adsorption, mucus penetration, release and transport properties of Lip-SeNPs in vitro. Thiolated Lip-SeNPs were positively charged with an average size of about 250 nm. Thiolated Lip- SeNPs tightly adhered to the mucus layer without penetrating the enterocytes. This finding was consistent with ex vivo adsorption studies using freshly excised porcine small intestinal tissues. Due to the improved mucoadhesion and retention in a simulated microenvironment of the small intestine, thiolated Lip-SeNPs might be a promising tool for oral selenium delivery.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Kemija, Interdisciplinarne prirodne znanosti, Farmacija



POVEZANOST RADA

Projekti:

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Institut za fiziku, Zagreb

Profili:

Avatar Url Borna Radatović (autor)

Avatar Url Ivana Vinković Vrček (autor)

Avatar Url Atiđa Selmani (autor)

Poveznice na cjeloviti tekst rada:

doi mdpi-res.com

Citiraj ovu publikaciju:

Selmani, Atiđa; Seibert, Elisabeth; Tetyczka, Carolin; Kuehnelt, Doris; Vidaković, Ivan; Kornmueller, Karin; Absenger-Novak, Markus; Radatović, Borna; Vinković Vrček, Ivana; Leitinger, Gerd et al.
Thiolated Chitosan Conjugated Liposomes for Oral Delivery of Selenium Nanoparticles // Pharmaceutics, 14 (2022), 4; 803, 19 doi:10.3390/pharmaceutics14040803 (međunarodna recenzija, članak, znanstveni)
Selmani, A., Seibert, E., Tetyczka, C., Kuehnelt, D., Vidaković, I., Kornmueller, K., Absenger-Novak, M., Radatović, B., Vinković Vrček, I. & Leitinger, G. (2022) Thiolated Chitosan Conjugated Liposomes for Oral Delivery of Selenium Nanoparticles. Pharmaceutics, 14 (4), 803, 19 doi:10.3390/pharmaceutics14040803.
@article{article, author = {Selmani, Ati\dja and Seibert, Elisabeth and Tetyczka, Carolin and Kuehnelt, Doris and Vidakovi\'{c}, Ivan and Kornmueller, Karin and Absenger-Novak, Markus and Radatovi\'{c}, Borna and Vinkovi\'{c} Vr\v{c}ek, Ivana and Leitinger, Gerd and Fr\"{o}hlich, Eleonore and Bernkop- Schn\"{u}rch, Andreas and Roblegg, Eva and Prassl, Ruth}, year = {2022}, pages = {19}, DOI = {10.3390/pharmaceutics14040803}, chapter = {803}, keywords = {thiomers, microfluidic synthesis, biophysical characterization, in vitro intestinal model}, journal = {Pharmaceutics}, doi = {10.3390/pharmaceutics14040803}, volume = {14}, number = {4}, issn = {1999-4923}, title = {Thiolated Chitosan Conjugated Liposomes for Oral Delivery of Selenium Nanoparticles}, keyword = {thiomers, microfluidic synthesis, biophysical characterization, in vitro intestinal model}, chapternumber = {803} }
@article{article, author = {Selmani, Ati\dja and Seibert, Elisabeth and Tetyczka, Carolin and Kuehnelt, Doris and Vidakovi\'{c}, Ivan and Kornmueller, Karin and Absenger-Novak, Markus and Radatovi\'{c}, Borna and Vinkovi\'{c} Vr\v{c}ek, Ivana and Leitinger, Gerd and Fr\"{o}hlich, Eleonore and Bernkop- Schn\"{u}rch, Andreas and Roblegg, Eva and Prassl, Ruth}, year = {2022}, pages = {19}, DOI = {10.3390/pharmaceutics14040803}, chapter = {803}, keywords = {thiomers, microfluidic synthesis, biophysical characterization, in vitro intestinal model}, journal = {Pharmaceutics}, doi = {10.3390/pharmaceutics14040803}, volume = {14}, number = {4}, issn = {1999-4923}, title = {Thiolated Chitosan Conjugated Liposomes for Oral Delivery of Selenium Nanoparticles}, keyword = {thiomers, microfluidic synthesis, biophysical characterization, in vitro intestinal model}, chapternumber = {803} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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