Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1188908

Recognition of DNA:RNA hybrid and triplex structure by a series of benzothiazole ligands


Zonjić, Iva; Tumir, Lidija Marija; Šupljika, Filip; Crnolatac, Ivo; Racané, Livio; Tomić, Sanja; Radić Stojković Marijana
Recognition of DNA:RNA hybrid and triplex structure by a series of benzothiazole ligands // 27th Croatian Meeting of Chemists and Chemical Engineers / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna (ur.).
Zagreb: Hrvatsko kemijsko društvo, 2021. str. 44-44 (predavanje, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1188908 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Recognition of DNA:RNA hybrid and triplex structure by a series of benzothiazole ligands

Autori
Zonjić, Iva ; Tumir, Lidija Marija ; Šupljika, Filip ; Crnolatac, Ivo ; Racané, Livio ; Tomić, Sanja ; Radić Stojković Marijana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
27th Croatian Meeting of Chemists and Chemical Engineers / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna - Zagreb : Hrvatsko kemijsko društvo, 2021, 44-44

Skup
27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI)

Mjesto i datum
Veli Lošinj, Hrvatska, 05.10.2021. - 08.10.2021

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
DNA:RNA hybrids ; triplexes ; interactions ; benzothiazole ligands

Sažetak
DNA:RNA hybrids and triplexes are formed as intermediate structures during many biologically important processes such as DNA replication, transcription, telomere replication and modulation of structure and/or function of specific genes (antigene strategy for gene regulation).[1, 2, 3, 4] Interactions of an array of nucleic acid structures with a small series of benzothiazole ligands (1-9) were screened by competition dialysis assay (Figure 1). The main aim of this study was detection of benzothiazole structures with preferential binding to DNA:RNA hybrids and ATT triplex in regard to regular (non- hybrid) DNA and RNA duplexes and singlestranded forms. Complexes of nucleic acids and benzothiazoles, screened by this method, were then characterised by UV/Vis, fluorescence, circular dichroism (CD) spectroscopy, isothermal titration calorimetry and Compounds 1 and 6 showed the highest affinities toward 13 nucleic acid structures while 5, despite lower affinities, yielded higher selectivity among studied compounds. While both 6 and 1 exerted high binding affinities toward ATT, the latter showed stronger binding to rAdT hybrid whereas the former preferred dArU hybrid.

Izvorni jezik
Engleski



POVEZANOST RADA



Citiraj ovu publikaciju:

Zonjić, Iva; Tumir, Lidija Marija; Šupljika, Filip; Crnolatac, Ivo; Racané, Livio; Tomić, Sanja; Radić Stojković Marijana
Recognition of DNA:RNA hybrid and triplex structure by a series of benzothiazole ligands // 27th Croatian Meeting of Chemists and Chemical Engineers / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna (ur.).
Zagreb: Hrvatsko kemijsko društvo, 2021. str. 44-44 (predavanje, međunarodna recenzija, sažetak, znanstveni)
Zonjić, I., Tumir, L., Šupljika, F., Crnolatac, I., Racané, L., Tomić, S. & Radić Stojković Marijana (2021) Recognition of DNA:RNA hybrid and triplex structure by a series of benzothiazole ligands. U: Marković, D., Meštrović, E., Namjesnik, D. & Tomašić, V. (ur.)27th Croatian Meeting of Chemists and Chemical Engineers.
@article{article, author = {Zonji\'{c}, Iva and Tumir, Lidija Marija and \v{S}upljika, Filip and Crnolatac, Ivo and Racan\'{e}, Livio and Tomi\'{c}, Sanja}, year = {2021}, pages = {44-44}, keywords = {DNA:RNA hybrids, triplexes, interactions, benzothiazole ligands}, title = {Recognition of DNA:RNA hybrid and triplex structure by a series of benzothiazole ligands}, keyword = {DNA:RNA hybrids, triplexes, interactions, benzothiazole ligands}, publisher = {Hrvatsko kemijsko dru\v{s}tvo}, publisherplace = {Veli Lo\v{s}inj, Hrvatska} }
@article{article, author = {Zonji\'{c}, Iva and Tumir, Lidija Marija and \v{S}upljika, Filip and Crnolatac, Ivo and Racan\'{e}, Livio and Tomi\'{c}, Sanja}, year = {2021}, pages = {44-44}, keywords = {DNA:RNA hybrids, triplexes, interactions, benzothiazole ligands}, title = {Recognition of DNA:RNA hybrid and triplex structure by a series of benzothiazole ligands}, keyword = {DNA:RNA hybrids, triplexes, interactions, benzothiazole ligands}, publisher = {Hrvatsko kemijsko dru\v{s}tvo}, publisherplace = {Veli Lo\v{s}inj, Hrvatska} }




Contrast
Increase Font
Decrease Font
Dyslexic Font