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Pregled bibliografske jedinice broj: 1188389

Females have stronger neurogenic response than males after non-specific nasal challenge in patients with seasonal allergic rhinitis


Tomljenović, Dejan; Baudoin, Tomislav; Megla, Željka Bukovec; Geber, Goran; Scadding, Glenis; Kalogjera, Livije
Females have stronger neurogenic response than males after non-specific nasal challenge in patients with seasonal allergic rhinitis // Medical Hypotheses, 116 (2018), 114-118 doi:10.1016/j.mehy.2018.04.021 (međunarodna recenzija, članak, stručni)


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Naslov
Females have stronger neurogenic response than males after non-specific nasal challenge in patients with seasonal allergic rhinitis

Autori
Tomljenović, Dejan ; Baudoin, Tomislav ; Megla, Željka Bukovec ; Geber, Goran ; Scadding, Glenis ; Kalogjera, Livije

Izvornik
Medical Hypotheses (0306-9877) 116 (2018); 114-118

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
histamine ; hypertonic saline ; irritant index scale ; irritant rhinitis ; nasal challenge ; nasal challenge ; nasal hyperreactivity ; nasal lavage ; sex difference ; substance P

Sažetak
Epidemiological studies show female predominance in the prevalence of non- allergic rhinitis (NAR) and local allergic rhinitis (LAR). Experimental studies show female patients with allergic rhinitis (AR) demonstrate higher levels of sensitivity to irritants and airway hyperresponsiveness than males. Bronchial asthma shows female predominance in post-puberty patients, and gender interaction with severe asthma endotypes. Fibromyalgia, chronic fatigue syndrome, migraine and chronic cough, syndromes, which are commonly related to neurokinin substance P (SP) in the literature, also show strong female predominance. Studies have demonstrated that sex hormones, primarily oestrogens, affect mast cell activation. Mast cell proteases can amplify neurogenic inflammatory responses including the release of SP. Based on human epidemiological data and animal experimental data we hypothesized that female patients have different interaction between mast cell activation and neurogenic inflammation, i.e. substance P release, resulting in a different nasal symptom profile. To test the hypothesis we performed allergen and non-specific nasal challenges in patients with seasonal allergic rhinitis (SAR) out of season and looked for gender differences in subjective and objective responses. The interaction between subjective and objective reactivity was evaluated through the comparison of subjective symptom scores, concentrations of neurokinin substance P (SP) and cellular markers in nasal lavages after low doses of nasal allergen challenges. Female allergic subjects tended to have higher substance P (SP) concentrations both before and after non-specific challenges. The difference between post-allergen and post - hypertonic saline (HTS) challenge was highly significant in female patients (p = 0.001), while insignificant in male subjects (p = 0.14). Female patients had significantly stronger burning sensation after HTS challenge than male. These data indicate difference in the interaction between inflammatory cells and the neurogenic response, which is gender- related, and which may affect symptom profiles after challenges. Different regulation of neurogenic inflammation in females may have impact on symptoms and endotyping in respiratory disorders, not only in allergic rhinitis, but also asthma, chronic rhinosinusitis and irritant -induced cough.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Integrativna bioetika (prirodne, tehničke, biomedicina i zdravstvo, biotehničke, društvene, humanističke znanosti)



POVEZANOST RADA


Ustanove:
Stomatološki fakultet, Zagreb,
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice"

Profili:

Avatar Url Livije Kalogjera (autor)

Avatar Url Tomislav Baudoin (autor)

Avatar Url Goran Geber (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Tomljenović, Dejan; Baudoin, Tomislav; Megla, Željka Bukovec; Geber, Goran; Scadding, Glenis; Kalogjera, Livije
Females have stronger neurogenic response than males after non-specific nasal challenge in patients with seasonal allergic rhinitis // Medical Hypotheses, 116 (2018), 114-118 doi:10.1016/j.mehy.2018.04.021 (međunarodna recenzija, članak, stručni)
Tomljenović, D., Baudoin, T., Megla, Ž., Geber, G., Scadding, G. & Kalogjera, L. (2018) Females have stronger neurogenic response than males after non-specific nasal challenge in patients with seasonal allergic rhinitis. Medical Hypotheses, 116, 114-118 doi:10.1016/j.mehy.2018.04.021.
@article{article, author = {Tomljenovi\'{c}, Dejan and Baudoin, Tomislav and Megla, \v{Z}eljka Bukovec and Geber, Goran and Scadding, Glenis and Kalogjera, Livije}, year = {2018}, pages = {114-118}, DOI = {10.1016/j.mehy.2018.04.021}, keywords = {histamine, hypertonic saline, irritant index scale, irritant rhinitis, nasal challenge, nasal challenge, nasal hyperreactivity, nasal lavage, sex difference, substance P}, journal = {Medical Hypotheses}, doi = {10.1016/j.mehy.2018.04.021}, volume = {116}, issn = {0306-9877}, title = {Females have stronger neurogenic response than males after non-specific nasal challenge in patients with seasonal allergic rhinitis}, keyword = {histamine, hypertonic saline, irritant index scale, irritant rhinitis, nasal challenge, nasal challenge, nasal hyperreactivity, nasal lavage, sex difference, substance P} }
@article{article, author = {Tomljenovi\'{c}, Dejan and Baudoin, Tomislav and Megla, \v{Z}eljka Bukovec and Geber, Goran and Scadding, Glenis and Kalogjera, Livije}, year = {2018}, pages = {114-118}, DOI = {10.1016/j.mehy.2018.04.021}, keywords = {histamine, hypertonic saline, irritant index scale, irritant rhinitis, nasal challenge, nasal challenge, nasal hyperreactivity, nasal lavage, sex difference, substance P}, journal = {Medical Hypotheses}, doi = {10.1016/j.mehy.2018.04.021}, volume = {116}, issn = {0306-9877}, title = {Females have stronger neurogenic response than males after non-specific nasal challenge in patients with seasonal allergic rhinitis}, keyword = {histamine, hypertonic saline, irritant index scale, irritant rhinitis, nasal challenge, nasal challenge, nasal hyperreactivity, nasal lavage, sex difference, substance P} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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