Naslov
Francisella tularensis - one peculiar and possibly emerging pathogen

Autori
Marečić, Valentina ; Kelava, Ina ; Knežević, Maša ; Ožanič, Mateja ; Mihelčić, Mirna ; Šantić, Marina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
Medical Biodefence Conference

Mjesto i datum
München, Njemačka, 25.09.2021. - 30.09.2021

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Francisella, tularemia, emergent pathogen

Sažetak
Francisella tularensis is a gram-negative intracellular bacterium and the etiological agent of zoonotic and vector borne disease, tularemia in humans and animals. Due to ease of transmission, low infectious dose and severity of infection, subsp. tularensis has been classified as Tier 1 select agent. The bacterium has been isolated from more than 250 wild species, including protozoa cells in which Francisella could persists for years. There are many species and subspecies of francisela, and many models that have been used for studying this peculiar pathogen. In addition, Francisella uptake and replication occurs in a variety of cell types including phagocytic and non-phagocytic cells. Our studies have showed that different species behave differently in terms of pathogenesis in an in vitro and in vivo model. Interestingly, francisela exhibits an alteration in the resistance to disinfectants after being growing in amoeba. This overview will summarize the important aspects from ecology of francisela, pathogenesis of tularemia to epidemiology of this possibly emerging pathogen in Europe and worldwide.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne tehničke znanosti, Kliničke medicinske znanosti

POVEZANOST RADA