Naslov
QSAR analysis of quinazolinone Schiff bases antifungal activity
(QSAR analysis of quinazolinone Schiff bases antifungal activity)

Autori
Karnaš, Maja ; Šubarić, Domagoj ; Vrandečić, Karolina ; Rastija, Vesna ; Komar, Mario ; Molnar, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XIV Meeting of Young Chemical Engineers: Book of Abstracts / Žižek, Krunoslav ; Katančić, Zvonimir ; Kovačić, Marin - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2022, 118-118

Skup
XIV. susret mladih kemijskih inženjera (SMLKI 2022)

Mjesto i datum
Zagreb, Hrvatska, 24.02.2022. - 25.02.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
quinazolinone Schiff bases ; antifungal activity ; QSAR ; plant protection

Sažetak
Plant diseases and pests are responsible for many losses in agricultural production worldwide, proving that their control is crucial for crop farming today. The use of plant protection products has effectively limited these losses. However, some of the active ingredients of these products are toxic for humans and fauna or cause groundwater and soil pollution. Therefore, there is an urgent need to find new, environmentally and toxicologically acceptable active ingredients for plant protection. In this study, we have tested the antifungal activity of 19 quinazolinone based Schiff bases against Sclerotinia sclerotiorum (Lib.) de Bary, a necrotrophic fungal pathogen causing disease in a variety of plants. Most of the tested compounds showed very good fungal growth inhibition at 0.8 μmol/mL, with 8 compounds inhibiting mycelial growth by more than 80 %. QSAR techniques provide an insight into the relationship between structure and biological activity of compounds, presenting an alternative path for the design and development of new active ingredients for plant protection. To elucidate important structural and physicochemical characteristics of tested quinazolinone Schiff bases related to their increased antifungal activity, a QSAR analysis was performed.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Poljoprivreda (agronomija)

POVEZANOST RADA