Pregled bibliografske jedinice broj: 1187674
Ferritin light and heavy chain expression in the liver and kidneys of Wistar rats: aging, sex differences, and impact of gonadectomy
Ferritin light and heavy chain expression in the liver and kidneys of Wistar rats: aging, sex differences, and impact of gonadectomy // Arhiv za higijenu rada i toksikologiju, 73 (2022), 48-61 doi:10.2478/aiht-2022-73-3621 (međunarodna recenzija, članak, znanstveni)
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Naslov
Ferritin light and heavy chain expression in the
liver and kidneys of Wistar rats: aging, sex
differences, and impact of gonadectomy
Autori
Pavić Vulinović, Mirela ; Turčić, Petra ; Micek, Vedran ; Ljubojević, Marija
Izvornik
Arhiv za higijenu rada i toksikologiju (0004-1254) 73
(2022);
48-61
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
ferritin nanocage ; hepatocytes ; immunofluorescence ; intercalated cells, iron metabolism ; macula densa ; nephron ; steroid hormones ; western blot
Sažetak
Ferritin is the main intracellular storage of iron. Animal studies show that female liver and kidney express more ferritin and accumulate more iron than male. However, no study so far has investigated sex and age differences in light (FtL) and heavy (FtH) ferritin chain expression. To address this, we relied on specific antibodies and immunochemical methods to analyse the expression of both ferritin chains in the liver and kidney of 3-month and 2- year-old male and female Wistar rats. To see how sex hormones may affect expression we also studied adult animals gonadectomised at the age of 10 weeks. FtL and FtH were more expressed in both organs of female rats, while gonadectomy increased the expression in males and decreased it in females, which suggests that it is stimulated by female and inhibited by male steroid hormones. Normal kidney ferritin distribution and change with aging warrant more attention in studies of (patho) physiological and toxicological processes.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti, Veterinarska medicina, Interdisciplinarne biotehničke znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
POVEZANOST RADA
Projekti:
IP-2013-11-1481 - Starosno-ovisna ekspresija membranskih prijenosnika u štakora (AGEMETAR) (Sabolić, Ivan, HRZZ - 2013-11) ( CroRIS)
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Veterinarski fakultet, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE