Pregled bibliografske jedinice broj: 1187662
Association between BCL2, BCL2 E17, MCL1 and BAX Protein Expression, Bone Marrow Microenvironment Histological Features, Clinical Presentation, Therapeutic Outcome, and the Overall Survival in Newly Diagnosed Multiple Myeloma
Association between BCL2, BCL2 E17, MCL1 and BAX Protein Expression, Bone Marrow Microenvironment Histological Features, Clinical Presentation, Therapeutic Outcome, and the Overall Survival in Newly Diagnosed Multiple Myeloma // Blood, 138 (2021), 1; 4716-4717 doi:10.1182/blood-2021-154486 (međunarodna recenzija, ostalo, znanstveni)
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Naslov
Association between BCL2, BCL2 E17, MCL1 and BAX
Protein Expression, Bone Marrow Microenvironment
Histological Features, Clinical Presentation,
Therapeutic Outcome, and the Overall Survival in
Newly Diagnosed Multiple Myeloma
Autori
Škrtić, Anita ; Jaksić, Ozren ; Ostojić, Slobodanka ; Antica, Mariastefania ; Crnković, Petra ; Skelin, Josipa ; Jurenec, Silvana ; Habijanec, Borna ; Radić Kristo, Delfa
Izvornik
Blood (0006-4971) 138
(2021), 1;
4716-4717
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, ostalo, znanstveni
Ključne riječi
Multiple Myeloma ; BCL2 ; BCL2 E17 ; MCL1 ; BAX
Sažetak
We evaluated the correlation between immunohistochemical BCL2, BCL2 E17, MCL1 (Bcl2- related protein family) and BAX (effector proapoptotic protein) expression and intensity of staining in plasma cells (PC) in MM patients (pts) who were eligible for autologous stem cell transplantation (ASCT) with DD4, CD8, and FOXP3 positive Tregs lymphocytes in bone marrow (BM) microenvironment, morphologic features of PC, clinical parameters, and outcomes. Immunohistochemical staining of BCL2, BCL2 E17, MCL1, BAX, CD4, CD8, FOXP3 and Ki67 was performed in BM biopsy of 36 newly diagnosed MM patients who were eligible for ASCT between 2012-2017 at University Hospital Merkur. Pearson's and Spearmans's coefficients of correlation, t-tests, one-way independent sample ANOVAs, mixed ANOVAs, moderation analyses, chi-square tests of independence and Cox's proportional hazards were used to analyze the data.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
HRZZ-IP-2020-02-2431 - Obnova timusa za preciznu medicinu u liječenju tumora i leukemija (THYMINNOVA) (Antica, Mariastefania, HRZZ - 2020-02) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
Profili:
Mariastefania Antica
(autor)
Slobodanka Ostojić Kolonić
(autor)
Delfa Radić Krišto
(autor)
Anita Škrtić
(autor)
Josipa Skelin
(autor)
Ozren Jakšić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE