Naslov
Cycloaddition of Thiourea- and Guanidine-Substituted Furans to Dienophiles: A Comparison of the Environmentally-Friendly Methods

Autori
Barešić, Luka ; Margetić, Davor ; Glasovac, Zoran

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Chemistry proceedings, 2021, 3(1), / - : MDPI Books, 2021

Skup
24th International Electronic Conference on Synthetic Organic Chemistry

Mjesto i datum
Online, 15.11.2020. - 15.12.2020

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cycloaddition ; guanidine ; microwave assisted organic reactions ; high pressure ; high speed vibrational milling ; ultrasound

Sažetak
The cycloaddition strategy was employed in order to obtain a 7-oxanorbornene framework substituted with a guanidine moiety or its precursor functional groups: protected amine or thiourea. In order to optimize the conditions for the cycloaddition, several environmentally-friendly methods—microwave assisted organic synthesis, high pressure synthesis, high speed vibrational milling, and ultrasound assisted synthesis—were employed. The outcomes of the cycloaddition reactions were interpreted in terms of endo/exo selectivity, the conversion of the reactants to the product, and the isolated yields. In general, our results indicated the HP and HSVM approaches as the methods of choice to give good yields and conversions.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA