Naslov
Genetic regulation of post-translational modification of two distinct proteins

Autori
Landini, Arianna ; Trbojević-Akmačić, Irena ; Navarro, Pau ; Tsepilov, Yakov A. ; Sharapov, Sodbo Z ; Vučković, Frano ; Polašek, Ozren ; Hayward, Caroline ; Petrović, Tea ; Vilaj, Marija ; Aulchenko, Yurii S. ; Lauc, Gordan ; Wilson, James F. ; Klarić, Lucija

Izvornik
Nature Communications (2041-1723) 13 (2022); 1586, 13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
post-translational modifications ; transferrin ; immunoglobulin G ; glycosylation

Sažetak
Post-translational modifications diversify protein functions and dynamically coordinate their signalling networks, influencing most aspects of cell physiology. Nevertheless, their genetic regulation or influence on complex traits is not fully understood. Here, we compare the genetic regulation of the same PTM of two proteins – glycosylation of transferrin and immunoglobulin G (IgG). By performing genome-wide association analysis of transferrin glycosylation, we identify 10 significantly associated loci, 9 of which were not reported previously. Comparing these with IgG glycosylation-associated genes, we note protein- specific associations with genes encoding glycosylation enzymes (transferrin - MGAT5, ST3GAL4, B3GAT1 ; IgG - MGAT3, ST6GAL1), as well as shared associations (FUT6, FUT8). Colocalisation analyses of the latter suggest that different causal variants in the FUT genes regulate fucosylation of the two proteins. Glycosylation of these proteins is thus genetically regulated by both shared and protein- specific mechanisms.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

POVEZANOST RADA