Pregled bibliografske jedinice broj: 1185504
Humoral immune response to COVID-19 vaccines in people with secondary progressive multiple sclerosis treated with siponimod
Humoral immune response to COVID-19 vaccines in people with secondary progressive multiple sclerosis treated with siponimod // Multiple Sclerosis and Related Disorders, 57 (2022), 103435, 3 doi:10.1016/j.msard.2021.103435 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1185504 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Humoral immune response to COVID-19 vaccines in people with secondary progressive multiple sclerosis treated with siponimod
Autori
Krbot Skorić, Magdalena ; Rogić, Dunja ; Lapić, Ivana ; Šegulja, Dragana ; Habek, Mario
Izvornik
Multiple Sclerosis and Related Disorders (2211-0348) 57
(2022);
103435, 3
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
COVID-19 ; SARS-CoV-2 IgG antibody ; secondary progressive multiple sclerosis ; siponimod ; vaccines
Sažetak
Objective: The aim of this study is to determine a development of humoral response after COVID-19 vaccination in persons with secondary progressive multiple sclerosis (pwSPMS) on siponimod, compared to healthy controls (HC). Methods: In 13 pwSPMS taking siponimod and 11 HC, testing for SARS-CoV2 antibodies was performed after vaccination against COVID-19. Results: pwSPMS taking siponimod had a significantly lower titer of SARS-CoV2 antibodies compared to healthy controls (19.4 (0-250) vs. 250 (250), p>0.001). Two (15.4%) pwSPMS on siponimod had unmeasurable titers of SARS-CoV2-2 antibodies, while all HC had positive titers. Conclusion: Although the results of this study are limited by a small sample size, results have consistently shown low titers of SARS-CoV-2 IgG after COVID-19 vaccinations in pwSPMS on siponimod.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Fakultet elektrotehnike i računarstva, Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb
Profili:
Dunja Rogić (autor)
Dragana Šegulja (autor)
Ivana Lapić (autor)
MAGDALENA KRBOT SKORIĆ (autor)
Mario Habek (autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE