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Pregled bibliografske jedinice broj: 1185504

Humoral immune response to COVID-19 vaccines in people with secondary progressive multiple sclerosis treated with siponimod


Krbot Skorić, Magdalena; Rogić, Dunja; Lapić, Ivana; Šegulja, Dragana; Habek, Mario
Humoral immune response to COVID-19 vaccines in people with secondary progressive multiple sclerosis treated with siponimod // Multiple Sclerosis and Related Disorders, 57 (2022), 103435, 3 doi:10.1016/j.msard.2021.103435 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1185504 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Humoral immune response to COVID-19 vaccines in people with secondary progressive multiple sclerosis treated with siponimod

Autori
Krbot Skorić, Magdalena ; Rogić, Dunja ; Lapić, Ivana ; Šegulja, Dragana ; Habek, Mario

Izvornik
Multiple Sclerosis and Related Disorders (2211-0348) 57 (2022); 103435, 3

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
COVID-19 ; SARS-CoV-2 IgG antibody ; secondary progressive multiple sclerosis ; siponimod ; vaccines

Sažetak
Objective: The aim of this study is to determine a development of humoral response after COVID-19 vaccination in persons with secondary progressive multiple sclerosis (pwSPMS) on siponimod, compared to healthy controls (HC). Methods: In 13 pwSPMS taking siponimod and 11 HC, testing for SARS-CoV2 antibodies was performed after vaccination against COVID-19. Results: pwSPMS taking siponimod had a significantly lower titer of SARS-CoV2 antibodies compared to healthy controls (19.4 (0-250) vs. 250 (250), p>0.001). Two (15.4%) pwSPMS on siponimod had unmeasurable titers of SARS-CoV2-2 antibodies, while all HC had positive titers. Conclusion: Although the results of this study are limited by a small sample size, results have consistently shown low titers of SARS-CoV-2 IgG after COVID-19 vaccinations in pwSPMS on siponimod.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Fakultet elektrotehnike i računarstva, Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Krbot Skorić, Magdalena; Rogić, Dunja; Lapić, Ivana; Šegulja, Dragana; Habek, Mario
Humoral immune response to COVID-19 vaccines in people with secondary progressive multiple sclerosis treated with siponimod // Multiple Sclerosis and Related Disorders, 57 (2022), 103435, 3 doi:10.1016/j.msard.2021.103435 (međunarodna recenzija, članak, znanstveni)
Krbot Skorić, M., Rogić, D., Lapić, I., Šegulja, D. & Habek, M. (2022) Humoral immune response to COVID-19 vaccines in people with secondary progressive multiple sclerosis treated with siponimod. Multiple Sclerosis and Related Disorders, 57, 103435, 3 doi:10.1016/j.msard.2021.103435.
@article{article, author = {Krbot Skori\'{c}, Magdalena and Rogi\'{c}, Dunja and Lapi\'{c}, Ivana and \v{S}egulja, Dragana and Habek, Mario}, year = {2022}, pages = {3}, DOI = {10.1016/j.msard.2021.103435}, chapter = {103435}, keywords = {COVID-19, SARS-CoV-2 IgG antibody, secondary progressive multiple sclerosis, siponimod, vaccines}, journal = {Multiple Sclerosis and Related Disorders}, doi = {10.1016/j.msard.2021.103435}, volume = {57}, issn = {2211-0348}, title = {Humoral immune response to COVID-19 vaccines in people with secondary progressive multiple sclerosis treated with siponimod}, keyword = {COVID-19, SARS-CoV-2 IgG antibody, secondary progressive multiple sclerosis, siponimod, vaccines}, chapternumber = {103435} }
@article{article, author = {Krbot Skori\'{c}, Magdalena and Rogi\'{c}, Dunja and Lapi\'{c}, Ivana and \v{S}egulja, Dragana and Habek, Mario}, year = {2022}, pages = {3}, DOI = {10.1016/j.msard.2021.103435}, chapter = {103435}, keywords = {COVID-19, SARS-CoV-2 IgG antibody, secondary progressive multiple sclerosis, siponimod, vaccines}, journal = {Multiple Sclerosis and Related Disorders}, doi = {10.1016/j.msard.2021.103435}, volume = {57}, issn = {2211-0348}, title = {Humoral immune response to COVID-19 vaccines in people with secondary progressive multiple sclerosis treated with siponimod}, keyword = {COVID-19, SARS-CoV-2 IgG antibody, secondary progressive multiple sclerosis, siponimod, vaccines}, chapternumber = {103435} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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