Naslov
Immunoglobulin G glycome composition in transition from premenopause to postmenopause

Autori
Deriš, Helena ; Kifer, Domagoj ; Cindrić, Ana ; Petrović, Tea ; Cvetko, Ana ; Trbojević-Akmačić, Irena ; Kolčić, Ivana ; Polašek, Ozren ; Newson, Louise ; Spector, Tim ; Menni, Cristina ; Lauc, Gordan

Izvornik
IScience (2589-0042) 25 (2022), 3; 103897, 13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Glycomics ; Molecular biology ; Reproductive medicine

Sažetak
Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause. Using ultra-high- performance liquid chromatography, we analyzed IgG glycome composition in 5, 080 samples from 1940 pre-, peri-, and postmenopausal women. Statistically significant decrease in galactosylation and sialylation was observed in postmenopausal women. Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr ; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr ; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr ; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods. The conversion to the more proinflammatory IgG glycome and the resulting decrease in the ability of IgG to suppress low-grade chronic inflammation may be an important molecular mechanism mediating the increased health risk in perimenopause and postmenopause.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

POVEZANOST RADA