Naslov
Comparative analysis of azithromycin and ciprofloxacin in the treatment of chronic prostatitis caused by Chlamydia trachomatis

Autori
Škerk, Višnja ; Schonwald, Slavko ; Krhen, Ivan ; Banaszak, Artur ; Begovac, Josip ; Strugar, Jadranka ; Strapac, Zvonimir ; Vrsalovic , Renata ; Vukovic, Jacinta ; Tomas, Margita

Izvornik
International journal of antimicrobial agents (0924-8579) 21 (2003), 5; 457-462

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
prostatitis ; klamidija trahomatis ; azitromicin ; ciprofloksacin
(prostatitis ; Chalmydia trachomatis ; azithromycin ; ciprofloxacin)

Sažetak
A total of 89 patients, (> 18 years), with symptoms of chronic prostatitis and inflammatory findings as well as the presence of Chlamydia trachomatis confirmed by DNA/RNA DIGENE hybridization method and/or by isolation, McCoy culture and Lugol stain in expressed prostatic secretion or in voided bladder urine collected immediately after prostatic massage, were examined. The patients were randomized to receive a total of 4.5 g of azithromycin for 3 weeks, given as a 3-day therapy of 1 x 500 mg weekly or ciprofloxacin 500 mg b.i.d. for 20 days. Patients' sexual partners were treated at the same time. Clinical and bacteriological efficacy were evaluated 4-6 weeks after the end of therapy. Significantly higher eradication (36/45: 17/44 ; P = 0.0002) and a significantly higher clinical cure (31/45: 15/44 ; P=0.0021) were achieved in the group of patients treated with azithromycin than in the ciprofloxacin group.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina, Farmacija

POVEZANOST RADA