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Pregled bibliografske jedinice broj: 1183587

The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus


Vičić, Marijana; Sotošek, Vlatka; Brajac, Ines; Kaštelan, Marija; Prpić-Massari, Larisa
The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus // Medical hypotheses, 149 (2021), 110546, 3 doi:10.1016/j.mehy.2021.110546 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1183587 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus

Autori
Vičić, Marijana ; Sotošek, Vlatka ; Brajac, Ines ; Kaštelan, Marija ; Prpić-Massari, Larisa

Izvornik
Medical hypotheses (0306-9877) 149 (2021); 110546, 3

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cytotoxicity ; Granulysin ; Granzyme B ; Lichen planus ; Perforin
(Cytotoxicity ; Granulysin ; Granzyme B ; Lichen planus ; Perforin.)

Sažetak
Lichen planus is a chronic mucocutanous disorder histopathologically characterized with a keratinocytes apoptosis, subsequent basal cell layer liquefaction and accumulation of the inflammatory infiltrate in papillary dermis. A formation of apoptotic bodies in basal cell layer is due to a cytotoxic lymphocyte attack to the basal keratinocytes. It has been demonstrated that the cytotoxic molecules included in this attack are perforin and granzyme B. Both molecules are found upregulated in CD8+ lymphocytes that are in close contact to keratinocytes. However, their amount is lower in lichen planus than in other skin disease characterized by liquefaction and vacuolar degeneration of the basal epidermal layer. This could speculate about other cytotoxic molecule such as granulysin that could mediate keratinocyte apoptosis. Therefore, in this article we hypothesize about the crucial role of granulysin molecule in keratinocytes killing that could contribute to a lichen planus pathogenesis.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
--uniri-biomed-18-83 - Uloga citotoksičnosti posredovane granulizinom i perforinom 2 u nastanku psorijaze i lihen planusa (Prpić Massari, Larisa) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Vičić, Marijana; Sotošek, Vlatka; Brajac, Ines; Kaštelan, Marija; Prpić-Massari, Larisa
The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus // Medical hypotheses, 149 (2021), 110546, 3 doi:10.1016/j.mehy.2021.110546 (međunarodna recenzija, članak, znanstveni)
Vičić, M., Sotošek, V., Brajac, I., Kaštelan, M. & Prpić-Massari, L. (2021) The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus. Medical hypotheses, 149, 110546, 3 doi:10.1016/j.mehy.2021.110546.
@article{article, author = {Vi\v{c}i\'{c}, Marijana and Soto\v{s}ek, Vlatka and Brajac, Ines and Ka\v{s}telan, Marija and Prpi\'{c}-Massari, Larisa}, year = {2021}, pages = {3}, DOI = {10.1016/j.mehy.2021.110546}, chapter = {110546}, keywords = {Cytotoxicity, Granulysin, Granzyme B, Lichen planus, Perforin}, journal = {Medical hypotheses}, doi = {10.1016/j.mehy.2021.110546}, volume = {149}, issn = {0306-9877}, title = {The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus}, keyword = {Cytotoxicity, Granulysin, Granzyme B, Lichen planus, Perforin}, chapternumber = {110546} }
@article{article, author = {Vi\v{c}i\'{c}, Marijana and Soto\v{s}ek, Vlatka and Brajac, Ines and Ka\v{s}telan, Marija and Prpi\'{c}-Massari, Larisa}, year = {2021}, pages = {3}, DOI = {10.1016/j.mehy.2021.110546}, chapter = {110546}, keywords = {Cytotoxicity, Granulysin, Granzyme B, Lichen planus, Perforin.}, journal = {Medical hypotheses}, doi = {10.1016/j.mehy.2021.110546}, volume = {149}, issn = {0306-9877}, title = {The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus}, keyword = {Cytotoxicity, Granulysin, Granzyme B, Lichen planus, Perforin.}, chapternumber = {110546} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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