Pregled bibliografske jedinice broj: 1183587
The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus
The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus // Medical hypotheses, 149 (2021), 110546, 3 doi:10.1016/j.mehy.2021.110546 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1183587 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
The possible involvement of granulysin mediated
cytotoxicity in keratinocytes disruption in lichen
planus
Autori
Vičić, Marijana ; Sotošek, Vlatka ; Brajac, Ines ; Kaštelan, Marija ; Prpić-Massari, Larisa
Izvornik
Medical hypotheses (0306-9877) 149
(2021);
110546, 3
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Cytotoxicity ; Granulysin ; Granzyme B ; Lichen planus ; Perforin
(Cytotoxicity ; Granulysin ; Granzyme B ; Lichen planus ; Perforin.)
Sažetak
Lichen planus is a chronic mucocutanous disorder histopathologically characterized with a keratinocytes apoptosis, subsequent basal cell layer liquefaction and accumulation of the inflammatory infiltrate in papillary dermis. A formation of apoptotic bodies in basal cell layer is due to a cytotoxic lymphocyte attack to the basal keratinocytes. It has been demonstrated that the cytotoxic molecules included in this attack are perforin and granzyme B. Both molecules are found upregulated in CD8+ lymphocytes that are in close contact to keratinocytes. However, their amount is lower in lichen planus than in other skin disease characterized by liquefaction and vacuolar degeneration of the basal epidermal layer. This could speculate about other cytotoxic molecule such as granulysin that could mediate keratinocyte apoptosis. Therefore, in this article we hypothesize about the crucial role of granulysin molecule in keratinocytes killing that could contribute to a lichen planus pathogenesis.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
--uniri-biomed-18-83 - Uloga citotoksičnosti posredovane granulizinom i perforinom 2 u nastanku psorijaze i lihen planusa (Prpić Massari, Larisa) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka
Profili:
Marijana Vičić
(autor)
Vlatka Sotošek
(autor)
Larisa Prpić Massari
(autor)
Ines Brajac
(autor)
Marija Kaštelan
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE