Pregled bibliografske jedinice broj: 1183582
Current Concepts of Psoriasis Immunopathogenesis
Current Concepts of Psoriasis Immunopathogenesis // International journal of molecular sciences, 22 (2021), 21; 11574, 14 doi:10.3390/ijms222111574 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1183582 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Current Concepts of Psoriasis Immunopathogenesis
Autori
Vičić, Marijana ; Kaštelan, Marija ; Brajac, Ines ; Sotošek, Vlatka ; Prpić Massari, Larisa
Izvornik
International journal of molecular sciences (1422-0067) 22
(2021), 21;
11574, 14
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
psoriasis ; etiology ; immunopathogenesis ; T lymphocytes ; dendritic cells ; keratinocytes ; macrophages ; NK cells ; NKT cells ; IL-23/Th17 pathway
Sažetak
Psoriasis is a recurrent, chronic, immune- mediated, systemic inflammatory disease of the skin, joints, and other organic systems. After atopic dermatitis, chronic stationary psoriasis is the most common inflammatory skin disease, affecting an average of 2-4% of the world's population. The disease carries a significant burden due to its numerous comorbidities and the major impact on patients' social and emotional aspects of life. According to current knowledge, psoriasis is a multifactorial disease that occurs in genetically predisposed individuals under various environmental factors, which trigger an immune response disorder with a series of complex inflammatory cascades. The disease is initiated and maintained by mutual interaction of the innate and adaptive immune cells, primarily dendritic cells, T lymphocytes, and keratinocytes, whose leading role alternates at different stages of the disease, consisting mainly in the IL-23/Th17 pathway. Inflammatory events result in consequent epidermal and dermal changes and evolution of the characteristic psoriatic phenotype, respectively. This paper aims to present a comprehensive overview of current knowledge on psoriasis genetic and environmental etiological factors, immunopathogenesis, and the leading cellular and cytokine participants in the inflammatory pathways of this disease.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
--uniri-biomed-18-83 - Uloga citotoksičnosti posredovane granulizinom i perforinom 2 u nastanku psorijaze i lihen planusa (Prpić Massari, Larisa) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka
Profili:
Marijana Vičić
(autor)
Vlatka Sotošek
(autor)
Larisa Prpić Massari
(autor)
Ines Brajac
(autor)
Marija Kaštelan
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE