Naslov
Epidemiological characteristics, baseline clinical features, and outcomes of critically ill patients treated in a coronavirus disease 2019 tertiary center in continental Croatia

Autori
Čučković, Marcela ; Drmić, Željka ; Pražetina, Marko ; Tipura, Danijela ; Ćurčić, Maja ; Miko, Ivan ; Mihelčić, Antonija ; Romić, Andrea ; Kukoč, Andrea ; Blagaj, Vanja ; Lasić, Hrvoje ; Dolenc, Emil ; Hleb, Sonja ; Almahariq, Hani ; Šribar, Andrej ; Peršec, Jasminka ; Lukšić, Ivica

Izvornik
Croatian medical journal (0353-9504) 63 (2022), 1; 6-15

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
COVID-19 ; critical illness ; intensive care units ; clinical features ; laboratory findings ; mechanical ventilation

Sažetak
Aim: To describe epidemiological characteristics and baseline clinical features, laboratory findings at intensive care unit (ICU) admission, and survival rates of critically ill coronavirus disease 2019 (COVID-19) patients treated at a tertiary institution specialized for COVID-19 patients. Methods: This retrospective study recruited 692 patients (67.1% men). Baseline demographic data, major comorbidities, anthropometric measurements, clinical features, and laboratory findings at admission were compared between survivors and non- survivors. Results: The median age was 72 (64-78) years. The median body mass index was 29.1 kg/m2. The most relevant comorbidities were diabetes mellitus (32.6%), arterial hypertension (71.2%), congestive heart failure (19.1%), chronic kidney disease (12.6%), and hematological disorders (10.3%). The median number of comorbidities was 3 and median Charlson Comorbidity Index (CCI) was 5. A total of 61.8% patients received high-flow nasal oxygen therapy (HFNO) and 80.5% received mechanical ventilation (MV). Median duration of HFNO was 3, and that of MV was 7 days. ICU mortality rate was 72.7%. Survivors had significantly lower age, number of comorbidities, CCI, sequential organ failure assessment score, serum ferritin, C- reactive protein, D-dimer, and procalcitonin, interleukin- 6, lactate, white blood cell, and neutrophil counts. They also had higher lymphocyte counts, PaO2/FiO2 ratio, and glomerular filtration rate at admission. Length of ICU stay was 9 days. The median survival was 11 days for mechanically ventilated patients, and 24 days for patients who were not mechanically ventilated. Conclusion: The parameters that differentiate survivors from non- survivors are in agreement with published data. Further multivariate analyses are warranted to identify individual mortality risk factors.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA