Naslov
Comparison of intracervical and intravaginal prostaglandin E2 for induction of labor in term pregnancies with unfavorable cervix: randomized controlled trial

Autori
Vince, Katja ; Matijević, Ratko

Izvornik
European journal of obstetrics, gynecology, and reproductive biology (0301-2115) 270 (2022); 100-104

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
labor induction ; prostaglandin E2 ; dinoprostone ; unfavorable cervix

Sažetak
Objective. The aim of this study was to compare intracervical (IC) and intravaginal (IV) application of prostaglandin E2 (PGE2) for labor induction in term pregnancies with unfavorable cervix. Study design. This prospective randomized trial included 212 pregnant women with term pregnancy and unfavorable cervix randomly assigned for labor induction with either IC (0.5mg) or IV (2mg) PGE2 formulation. Main outcome measured was time interval from labor induction to delivery. Difference in mode of delivery and adverse perinatal outcomes between two studied groups was also investigated. Significance was set at p < 0.05. Results. Studied groups did not significantly differ regarding main characteristics such as age, parity, body mass index or Bishop score. Women in IV group compared to those in IC group had shorter induction to delivery time interval (p<0.001) and induction to active phase time interval (p=0.001), higher prevalence of vaginal delivery within 24 hours of labor induction (63, 3% vs 40, 6%, p=0.002) and higher prevalence of successful induction of labor (95, 9% vs. 86, 5%, p=0.020). The analysis did not reveal significant difference in mode of delivery between groups (p=0.453) or other adverse perinatal outcomes. Conclusion. IV application of PGE2 compared to IC application is more effective and comparably safe for labor induction in term pregnancies with unfavorable cervix and should be the method of choice for labor induction.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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