Naslov
Prognostic factors in mammary analogue secretory carcinomas of the parotid gland: Systematic review and meta-analysis
(Prognostic factors in mammary analogue secretory carcinomas of the parotid gland: Systematic review and meta‐analysis)

Autori
Janik, Stefan ; Faisal, Muhammad ; Marijić, Blazen ; Grasl, Stefan ; Grasl, Matthaeus Ch. ; Heiduschka, Gregor ; Erovic, Boban M.

Izvornik
Head & Neck (1043-3074) 44 (2021), 3; 792-804

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
mammary analogue secretory carcinoma ; MASC ; secretory carcinoma ; parotid gland ; prognosis ; outcome

Sažetak
Mammary analogue secretory carcinomas (MASCs) of the parotid gland are considered as low-grade malignancies with good clinical outcome but lacking data regarding prognostic factors. We performed meta-analysis assessing prognostic factors for disease-free survival (DFS) and overall survival (OS) in 256 patients with MASCs of the parotid gland. A total of 73 studies have met the inclusion criteria and 76.3% of patients were seen with T1 and T2 tumors and negative neck nodes. Lymph node metastasis (57.4%) and distant recurrences (46.2%) were particularly found in T4 tumors (p < 0.001). DFS at 5 and 10 years was 77.9% and 47.2% compared to 88.1% and 77.2% for OS at the same time points. Male sex, T3-T4 tumors, and recurrent disease represented independent worse prognosticators for survival outcome. Altogether, parotid gland MASCs show the good long-term outcomes, but T4 tumors behave significantly more aggressive and require extended treatment strategies along with close follow-ups.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA