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Pregled bibliografske jedinice broj: 1182949

2- and 2,7-substituted pyridine pyrenes derivatives and their DNA/RNA interactions

Košćak, Marta; Piantanida, Ivo; Božinović, Ksenija; Majhen, Dragomira; Kumar Kole; Goutam; Marder, Todd B.
2- and 2,7-substituted pyridine pyrenes derivatives and their DNA/RNA interactions // 2- and 2, 7-substituted pyridine pyrenes derivatives and their DNA/RNA interactions / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna (ur.).
Veli Lošinj: Hrvatsko kemijsko društvo, 2021. str. 85-85 (predavanje, domaća recenzija, sažetak, znanstveni)

CROSBI ID: 1182949 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
2- and 2,7-substituted pyridine pyrenes derivatives and their DNA/RNA interactions

Autori
Košćak, Marta ; Piantanida, Ivo ; Božinović, Ksenija ; Majhen, Dragomira ; Kumar Kole ; Goutam ; Marder, Todd B.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
2- and 2, 7-substituted pyridine pyrenes derivatives and their DNA/RNA interactions / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna - Veli Lošinj : Hrvatsko kemijsko društvo, 2021, 85-85

Skup
27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI) ; 5. simpozij Vladimir Prelog

Mjesto i datum
Veli Lošinj, Hrvatska, 05.10.2021. - 08.10.2021

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
2- i 2, 7-piridin pireni ; nekovalentne interakcije s DNA/RNA ; fluorescencija ; citotoksičnost ; ROS specije
(2- and 2, 7-pyridine pyrenes ; noncovalent interactions with DNA/RNA ; fluorescence ; cytotoxicity ROS species)

Sažetak
Pyrene is one of the most frequently studied fluorophore due to its environmental emission sensitivity and tendency to excimers and exciplexes formation. 1-, 3-, 6- and 8-substituted pyrenes are already well known, while 2- and 7- substituted ones are less researched while possesing very interesting photophysical properties. Planar structure of pyrene allows “aromatic stacking” with nucleobases, also intercalation between DNA/RNA basepairs and possibility of groove binding. Our preliminary studies indicated strong interactions of cationic analogues (1M and 2M) with ct-DNA, mainly based on intercalation. Only the monocation 1M showed a pronounced fluorescent selectivity between various DNAs and RNAs, in contrast to the less selective 2M. Neutral, monopyridine analogue 1 binds to DNA upon protonation at pH 5 (biorelevant because of tumor tissues acidity), with increase in pyrene excimer emission. Biological studies on the lung tumor cell line (A549) indicated for 1, 1M, and 2M a significant increase in cytotoxicity upon illumination, which was explained by the singlet oxygen generation and the consequent intense action of ROS species. New compounds with an intense fluorescent response and photo-induced bioactivity are promising candidates for new theranostic agents.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija



POVEZANOST RADA

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Ivo Piantanida (autor)

Avatar Url Dragomira Majhen (autor)

Avatar Url Ksenija Božinović (autor)

Avatar Url Marta Jurković (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada 27hskiki.hkd.hr

Citiraj ovu publikaciju:

Košćak, Marta; Piantanida, Ivo; Božinović, Ksenija; Majhen, Dragomira; Kumar Kole; Goutam; Marder, Todd B.
2- and 2,7-substituted pyridine pyrenes derivatives and their DNA/RNA interactions // 2- and 2, 7-substituted pyridine pyrenes derivatives and their DNA/RNA interactions / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna (ur.).
Veli Lošinj: Hrvatsko kemijsko društvo, 2021. str. 85-85 (predavanje, domaća recenzija, sažetak, znanstveni)
Košćak, M., Piantanida, I., Božinović, K., Majhen, D., Kumar Kole, Goutam & Marder, T. (2021) 2- and 2,7-substituted pyridine pyrenes derivatives and their DNA/RNA interactions. U: Marković, D., Meštrović, E., Namjesnik, D. & Tomašić, V. (ur.)2- and 2, 7-substituted pyridine pyrenes derivatives and their DNA/RNA interactions.
@article{article, author = {Ko\v{s}\'{c}ak, Marta and Piantanida, Ivo and Bo\v{z}inovi\'{c}, Ksenija and Majhen, Dragomira and Marder, Todd B.}, year = {2021}, pages = {85-85}, keywords = {2- i 2, 7-piridin pireni, nekovalentne interakcije s DNA/RNA, fluorescencija, citotoksi\v{c}nost, ROS specije}, title = {2- and 2,7-substituted pyridine pyrenes derivatives and their DNA/RNA interactions}, keyword = {2- i 2, 7-piridin pireni, nekovalentne interakcije s DNA/RNA, fluorescencija, citotoksi\v{c}nost, ROS specije}, publisher = {Hrvatsko kemijsko dru\v{s}tvo}, publisherplace = {Veli Lo\v{s}inj, Hrvatska} }
@article{article, author = {Ko\v{s}\'{c}ak, Marta and Piantanida, Ivo and Bo\v{z}inovi\'{c}, Ksenija and Majhen, Dragomira and Marder, Todd B.}, year = {2021}, pages = {85-85}, keywords = {2- and 2, 7-pyridine pyrenes, noncovalent interactions with DNA/RNA, fluorescence, cytotoxicity ROS species}, title = {2- and 2,7-substituted pyridine pyrenes derivatives and their DNA/RNA interactions}, keyword = {2- and 2, 7-pyridine pyrenes, noncovalent interactions with DNA/RNA, fluorescence, cytotoxicity ROS species}, publisher = {Hrvatsko kemijsko dru\v{s}tvo}, publisherplace = {Veli Lo\v{s}inj, Hrvatska} }

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