Pregled bibliografske jedinice broj: 1182890
Synthesis of new purine and pyrimidine 1,1’- disubstituted ferrocene conjugates using mechanochemistry
Synthesis of new purine and pyrimidine 1,1’- disubstituted ferrocene conjugates using mechanochemistry // 27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI)
Veli Lošinj, Hrvatska, 2021. str. 150-150 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 1182890 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Synthesis of new purine and pyrimidine 1,1’-
disubstituted ferrocene conjugates using
mechanochemistry
Autori
Piškor, Martina ; Sačer, Leon ; Meščić Macan, Andrijana ; Raić-Malić Silvana
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Skup
27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI)
Mjesto i datum
Veli Lošinj, Hrvatska, 05.10.2021. - 08.10.2021
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
purine, pyrimidine, ferrocene, mechanochemistry
Sažetak
Resistance to currently available antitumor drugs and their low specificity calls for an intensive search for new, more efficient and selective therapeutic agents. Ferrocene has attracted particular attention in cancer drug research due to its stability in aqueous media, steric, electronic and redox properties as well as low toxicity [1]. In our previous study [2, 3], we prepared a number of purine and pyrimidine mono- substituted ferrocene derivatives with good anticancer activity in vitro. Keeping in mind the biological potency of aforementioned mono- substituted ferrocenes, by employing both conventional Cu(I) catalysed 1, 3-dipolar cycloaddition synthesis and liquid-assisted mechanochemical CuAAC synthesis, we have synthesised new conjugates of pyrimidine, purine and its bioisosteres and 1, 1’-disubstituted ferrocenes linked through the 1, 2, 3-triazole ring (Scheme 1). The mechanochemical method was more effective in terms of reducing the reaction time and enhancing the product yield compared to the classical solution-based synthesis.
Izvorni jezik
Hrvatski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
HRZZ-IP-2018-01-4682 - Novi spojevi temeljeni na bioizosterima purina za ispitivanje njihovih antitumorskih i antipatogenih djelovanja (PurBioCaPa) (Raić-Malić, Silvana, HRZZ - 2018-01) ( CroRIS)
Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb