Pregled bibliografske jedinice broj: 1182005
Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration- Resistant Prostate Cancer
Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration- Resistant Prostate Cancer // Genes, 13 (2022), 2; 383, 12 doi:10.3390/genes13020383 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1182005 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Alpha Satellite RNA Levels Are Upregulated in the
Blood of Patients with Metastatic Castration-
Resistant Prostate Cancer
Autori
Ljubić, Sven ; Sermek, Antonio ; Prgomet Sečan, Angela ; Prpić, Marin ; Jakšić, Blanka ; Murgić, Jure ; Fröbe, Ana ; Ugarković, Đurđica ; Feliciello, Isidoro
Izvornik
Genes (2073-4425) 13
(2022), 2;
383, 12
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
alpha satellite DNA ; transcription ; alpha satellite RNA ; prostate cancer ; blood biomarker
Sažetak
The aberrant overexpression of alpha satellite DNA is characteristic of many human cancers including prostate cancer ; however, it is not known whether the change in the alpha satellite RNA amount occurs in the peripheral tissues of cancer patients, such as blood. Here, we analyse the level of intracellular alpha satellite RNA in the whole blood of cancer prostate patients at different stages of disease and compare it with the levels found in healthy controls. Our results reveal a significantly increased level of intracellular alpha satellite RNA in the blood of metastatic cancers patients, particularly those with metastatic castration-resistant prostate cancer relative to controls. In the blood of patients with localised tumour, no significant change relative to the controls was detected. Our results show a link between prostate cancer pathogenesis and blood intracellular alpha satellite RNA levels. We discuss the possible mechanism which could lead to the increased level of blood intracellular alpha satellite RNA at a specific metastatic stage of prostate cancer. Additionally, we analyse the clinically accepted prostate cancer biomarker PSA in all samples and discuss the possibility that alpha satellite RNA can serve as a novel prostate cancer diagnostic blood biomarker.
Izvorni jezik
Engleski
Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
POVEZANOST RADA
Ustanove:
Stomatološki fakultet, Zagreb,
KBC "Sestre Milosrdnice"
Profili:
Jure Murgić
(autor)
Antonio Sermek
(autor)
Sven Ljubić
(autor)
Marin Prpić
(autor)
Đurđica Ugarković
(autor)
Ana Fröbe
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE