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Pregled bibliografske jedinice broj: 1182005

Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration- Resistant Prostate Cancer


Ljubić, Sven; Sermek, Antonio; Prgomet Sečan, Angela; Prpić, Marin; Jakšić, Blanka; Murgić, Jure; Fröbe, Ana; Ugarković, Đurđica; Feliciello, Isidoro
Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration- Resistant Prostate Cancer // Genes, 13 (2022), 2; 383, 12 doi:10.3390/genes13020383 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1182005 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration- Resistant Prostate Cancer

Autori
Ljubić, Sven ; Sermek, Antonio ; Prgomet Sečan, Angela ; Prpić, Marin ; Jakšić, Blanka ; Murgić, Jure ; Fröbe, Ana ; Ugarković, Đurđica ; Feliciello, Isidoro

Izvornik
Genes (2073-4425) 13 (2022), 2; 383, 12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
alpha satellite DNA ; transcription ; alpha satellite RNA ; prostate cancer ; blood biomarker

Sažetak
The aberrant overexpression of alpha satellite DNA is characteristic of many human cancers including prostate cancer ; however, it is not known whether the change in the alpha satellite RNA amount occurs in the peripheral tissues of cancer patients, such as blood. Here, we analyse the level of intracellular alpha satellite RNA in the whole blood of cancer prostate patients at different stages of disease and compare it with the levels found in healthy controls. Our results reveal a significantly increased level of intracellular alpha satellite RNA in the blood of metastatic cancers patients, particularly those with metastatic castration-resistant prostate cancer relative to controls. In the blood of patients with localised tumour, no significant change relative to the controls was detected. Our results show a link between prostate cancer pathogenesis and blood intracellular alpha satellite RNA levels. We discuss the possible mechanism which could lead to the increased level of blood intracellular alpha satellite RNA at a specific metastatic stage of prostate cancer. Additionally, we analyse the clinically accepted prostate cancer biomarker PSA in all samples and discuss the possibility that alpha satellite RNA can serve as a novel prostate cancer diagnostic blood biomarker.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Ustanove:
Stomatološki fakultet, Zagreb,
KBC "Sestre Milosrdnice"

Profili:

Avatar Url Jure Murgić (autor)

Avatar Url Antonio Sermek (autor)

Avatar Url Sven Ljubić (autor)

Avatar Url Marin Prpić (autor)

Avatar Url Đurđica Ugarković (autor)

Avatar Url Ana Fröbe (autor)

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com fulir.irb.hr

Citiraj ovu publikaciju:

Ljubić, Sven; Sermek, Antonio; Prgomet Sečan, Angela; Prpić, Marin; Jakšić, Blanka; Murgić, Jure; Fröbe, Ana; Ugarković, Đurđica; Feliciello, Isidoro
Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration- Resistant Prostate Cancer // Genes, 13 (2022), 2; 383, 12 doi:10.3390/genes13020383 (međunarodna recenzija, članak, znanstveni)
Ljubić, S., Sermek, A., Prgomet Sečan, A., Prpić, M., Jakšić, B., Murgić, J., Fröbe, A., Ugarković, Đ. & Feliciello, I. (2022) Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration- Resistant Prostate Cancer. Genes, 13 (2), 383, 12 doi:10.3390/genes13020383.
@article{article, author = {Ljubi\'{c}, Sven and Sermek, Antonio and Prgomet Se\v{c}an, Angela and Prpi\'{c}, Marin and Jak\v{s}i\'{c}, Blanka and Murgi\'{c}, Jure and Fr\"{o}be, Ana and Ugarkovi\'{c}, \DJur\djica and Feliciello, Isidoro}, year = {2022}, pages = {12}, DOI = {10.3390/genes13020383}, chapter = {383}, keywords = {alpha satellite DNA, transcription, alpha satellite RNA, prostate cancer, blood biomarker}, journal = {Genes}, doi = {10.3390/genes13020383}, volume = {13}, number = {2}, issn = {2073-4425}, title = {Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration- Resistant Prostate Cancer}, keyword = {alpha satellite DNA, transcription, alpha satellite RNA, prostate cancer, blood biomarker}, chapternumber = {383} }
@article{article, author = {Ljubi\'{c}, Sven and Sermek, Antonio and Prgomet Se\v{c}an, Angela and Prpi\'{c}, Marin and Jak\v{s}i\'{c}, Blanka and Murgi\'{c}, Jure and Fr\"{o}be, Ana and Ugarkovi\'{c}, \DJur\djica and Feliciello, Isidoro}, year = {2022}, pages = {12}, DOI = {10.3390/genes13020383}, chapter = {383}, keywords = {alpha satellite DNA, transcription, alpha satellite RNA, prostate cancer, blood biomarker}, journal = {Genes}, doi = {10.3390/genes13020383}, volume = {13}, number = {2}, issn = {2073-4425}, title = {Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration- Resistant Prostate Cancer}, keyword = {alpha satellite DNA, transcription, alpha satellite RNA, prostate cancer, blood biomarker}, chapternumber = {383} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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