Naslov
Chronic electrical stimulation of peripheral nerves via deep-red light transduced by an implanted organic photocapacitor

Autori
Silverå Ejneby, Malin ; Jakešová, Marie ; Ferrero, Jose J ; Migliaccio, Ludovico ; Sahalianov, Ihor ; Zhao, Zifang ; Berggren, Magnus ; Khodagholy, Dion ; Đerek, Vedran ; Gelinas, Jennifer N ; Głowacki, Eric Daniel

Izvornik
Nature biomedical engineering (2157-846X) (2022), 6; 741-753

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
bioelectronics, implant, oganic semiconductor, chronic, photovoltaic

Sažetak
Implantable devices for the wireless modulation of neural tissue need to be designed for reliability, safety and reduced invasiveness. Here we report chronic electrical stimulation of the sciatic nerve in rats by an implanted organic electrolytic photocapacitor that transduces deep-red light into electrical signals. The photocapacitor relies on commercially available semiconducting non-toxic pigments and is integrated in a conformable 0.1- mm3 thin-film cuff. In freely moving rats, fixation of the cuff around the sciatic nerve, 10 mm below the surface of the skin, allowed stimulation (via 50–1, 000-μs pulses of deep-red light at wavelengths of 638 nm or 660 nm) of the nerve for over 100 days. The robustness, biocompatibility, low volume and high-performance characteristics of organic electrolytic photocapacitors may facilitate the wireless chronic stimulation of peripheral nerves.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA