Pregled bibliografske jedinice broj: 1181233
Lymphocytic choriomeningitis - emerging trends of a neglected virus: a narrative review
Lymphocytic choriomeningitis - emerging trends of a neglected virus: a narrative review // Tropical medicine and infectious disease, 6 (2021), 2; 88, 19 doi:10.3390/tropicalmed6020088 (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 1181233 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Lymphocytic choriomeningitis - emerging trends of a neglected virus: a narrative review
Autori
Vilibić-Čavlek, Tatjana ; Savić, Vladimir ; Ferenc, Thomas ; Mrzljak, Anna ; Barbić, Ljubo ; Bogdanić, Maja ; Stevanović, Vladimir ; Tabain, Irena ; Ferenčak, Ivana ; Židovec-Lepej, Snježana
Izvornik
Tropical medicine and infectious disease (2414-6366) 6
(2021), 2;
88, 19
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
lymphocytic choriomeningitis virus ; epidemiology ; pregnancy ; transplant recipients
Sažetak
Lymphocytic choriomeningitis virus (LCMV) is a neglected rodent-borne zoonotic virus distributed worldwide. Since serologic assays are limited to several laboratories, the disease has been underreported, often making it difficult to determine incidence and seroprevalence rates. Although human clinical cases are rarely recorded, LCMV remains an important cause of meningitis in humans. In addition, a fatal donor-derived LCMV infection in several clusters of solid organ transplant recipients further highlighted a pathogenic potential and clinical significance of this virus. In the transplant populations, abnormalities of the central nervous system were also found, but were overshadowed by the systemic illness resembling the Lassa hemorrhagic fever. LCMV is also an emerging fetal teratogen. Hydrocephalus, periventricular calcifications and chorioretinitis are the predominant characteristics of congenital LCMV infection, occurring in 87.5% of cases. Mortality in congenitally infected children is about 35%, while 70% of them show long-term neurologic sequelae. Clinicians should be aware of the risks posed by LCMV and should consider the virus in the differential diagnosis of aseptic meningitis, especially in patients who reported contact with rodents. Furthermore, LCMV should be considered in infants and children with unexplained hydrocephalus, intracerebral calcifications and chorioretinitis. Despite intensive interdisciplinary research efforts, efficient antiviral therapy for LCMV infection is still not available.
Izvorni jezik
Engleski
Znanstvena područja
Javno zdravstvo i zdravstvena zaštita
POVEZANOST RADA
Ustanove:
Hrvatski zavod za javno zdravstvo,
Klinička bolnica "Merkur",
Hrvatski veterinarski institut, Zagreb,
Veterinarski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Klinika za infektivne bolesti "Dr Fran Mihaljević",
Klinički bolnički centar Zagreb
Profili:
Vladimir Stevanović
(autor)
Thomas Ferenc
(autor)
Tatjana Vilibić-Čavlek
(autor)
Ivana Ferenčak
(autor)
Ljubo Barbić
(autor)
Vladimir Savić
(autor)
Maja Bogdanić
(autor)
Irena Tabain
(autor)
Anna Mrzljak
(autor)
Snježana Židovec-Lepej
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Emerging Sources Citation Index (ESCI)
- Scopus