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Pregled bibliografske jedinice broj: 1180702

Immunological markers in neuroinvasive arboviral infections


Židovec Lepej, Snježana; Barbić, Ljubo; Sabadi, Dario; Perić, Ljiljana; Ilić, Maja; Tabain, Irena; Bogdanić, Maja; Grgić, Ivana; Gorenec, Lana; Savić, Vladimir et al.
Immunological markers in neuroinvasive arboviral infections // (Re-)emergentni arbovirusi u sjeni pandemije COVID-19 : program i knjiga sažetaka / Vilibić-Čavlek, Tatjana ; Barbić, Ljubo ; Savić, Vladimir ; Tabain, Irena ; Kaić, Bernard (ur.).
Zagreb, 2021. str. 34-35 (predavanje, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1180702 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Immunological markers in neuroinvasive arboviral infections
(Immunological markers in neuroinvasive arboviral infections)

Autori
Židovec Lepej, Snježana ; Barbić, Ljubo ; Sabadi, Dario ; Perić, Ljiljana ; Ilić, Maja ; Tabain, Irena ; Bogdanić, Maja ; Grgić, Ivana ; Gorenec, Lana ; Savić, Vladimir ; Potočnik-Hunjadi, Tanja ; Stevanović, Vladimir ; Dvorski, Elizabeta ; Butigan, Tamara ; Kolaric-Sviben, Gordana ; Vilibić-Čavlek, Tatjana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
(Re-)emergentni arbovirusi u sjeni pandemije COVID-19 : program i knjiga sažetaka / Vilibić-Čavlek, Tatjana ; Barbić, Ljubo ; Savić, Vladimir ; Tabain, Irena ; Kaić, Bernard - Zagreb, 2021, 34-35

ISBN
978-953-8362-10-1

Skup
Virtualni simpozij s međunarodnim sudjelovanjem " (Re-)emergentni arbovirusi u sjeni pandemije COVID-19"

Mjesto i datum
Zagreb, Hrvatska, 10.06.2021. - 11.06.2021

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
immunological markers ; tick-borne encephalitis virus ; West Nile virus ; Toscana virus

Sažetak
Objectives: Literature data on the immunopathogenesis of neuroinvasive arboviral infections, particularly in the context of complex cytokine immune responses, are limited. The aim of this study was to compare cytokine expression patterns in the cerebrospinal fluid (CSF) and serum in human neuroinvasive arboviral infections caused by tick-borne encephalitis virus (TBEV), West Nile virus (WNV) and Toscana virus (TOSV). Methods: Antiviral cytokine response in the serum and CSF was analysed by using a multiplex bead- based assay for simultaneous quantification of 13 human cytokines (LEGENDplex Human Th cytokine panel, BioLegend, USA) on FACS Canto II flow cytometer (Beckton Dickinson, USA). The panel included cytokines associated with innate and early pro-inflammatory immune responses (TNF-α, IL-6), Th1 type immune response (IL-2, IFN-γ), Th2 immune response (IL-4, IL-5, IL-9 and IL-13), Th17 immune response (IL-17A, IL-17F, IL-21 and IL-22) and the key anti-inflammatory cytokine IL-10. Results: Analysis of cytokine expression pattern in the CSF and serum of patients with neuroinvasive infection with TBEV (32 patients), WNV (68 patients) and TOSV (3 patients) revealed partially similar patterns. Significantly higher concentrations of IL-6 in the CSF vs. serum were found in both TBEV (median 780.88 pg/mL, IQR 130.81-3, 077.66 vs. median 23.25 pg/mL, IQR 7.79- 27.09, respectively ; p<0.001) and WNV (median 2, 036.71 pg/mL, IQR 213.82-6, 190.5 vs. median 24.48 pg/mL, IQR 11.93-49.81, respectively ; p<0.001) patient groups. Similarly, higher concentrations of IFN-γ in the CSF compared with serum have been shown in both TBEV (median 122.7 pg/mL, IQR 98.09- 246.04 vs. 27.28 pg/mL, IQR 14.81-37.75 ; p<0.001) and WNV patient groups (median 49.59 pg/mL, IQR 23.07-127.37 vs. 27.22 pg/mL, IQR 20.95-41.82 ; p=0.07). Expression of IL-2, IL-4, TNF-α and Th1 17 cytokines (IL-17A, IL-17F, IL-21) was detected in the serum but not in the CSF (except one positive CSF sample for IL-17F and IL-4). Th1 cytokine IL-13 was detectable in both serum and CSF of WNV patients but only in the serum of TBEV patients. In contrast, IL-22 and IL-5 were detectable in both serum and CSF of TBEV patients but only in the serum of WNV patients (except one positive CSF sample for IL-5). CSF samples of patients with Toscana neuroinvasive disease showed higher concentrations of IL-6, IFN-γ and IL-10 compared with corresponding serum samples. Conclusions: The results of this study show increased concentrations of the key cytokines associated with innate and early acute phase responses (IL-6) and Th1 type immune responses (IFN-γ) in the CNS of patients with neuroinvasive arbovirus infections. In contrast, expression of the key T-cell growth factor IL-2, Th17 cytokines, a Th2 cytokine IL-4 and the proinflammatory cytokine TNF-α appear to be concentrated mainly in the periphery. These findings suggest a well- defined pattern of cytokine biology in neuroinvasive arboviral infections. Further studies on the possible association between cytokine expression patterns and clinical severity of WNV, TBEV and TOSV neuroinvasive infections as well as on the underlying mechanisms of cellular immunity warrant further investigations.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekti:
HRZZ-IP-2016-06-7456 - Prevalencija i molekularna epidemiologija emergentnih i re-emergentnih neuroinvazivnih arbovirusnih infekcija na području Hrvatske (CRONEUROARBO) (Vilibić Čavlek, Tatjana, HRZZ - 2016-06) ( CroRIS)

Ustanove:
Hrvatski zavod za javno zdravstvo,
Hrvatski veterinarski institut, Zagreb,
Veterinarski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Osijek,
Klinika za infektivne bolesti "Dr Fran Mihaljević",
Opća bolnica Varaždin

Poveznice na cjeloviti tekst rada:

croneuroarbo.hzjz.hr

Citiraj ovu publikaciju:

Židovec Lepej, Snježana; Barbić, Ljubo; Sabadi, Dario; Perić, Ljiljana; Ilić, Maja; Tabain, Irena; Bogdanić, Maja; Grgić, Ivana; Gorenec, Lana; Savić, Vladimir et al.
Immunological markers in neuroinvasive arboviral infections // (Re-)emergentni arbovirusi u sjeni pandemije COVID-19 : program i knjiga sažetaka / Vilibić-Čavlek, Tatjana ; Barbić, Ljubo ; Savić, Vladimir ; Tabain, Irena ; Kaić, Bernard (ur.).
Zagreb, 2021. str. 34-35 (predavanje, međunarodna recenzija, sažetak, znanstveni)
Židovec Lepej, S., Barbić, L., Sabadi, D., Perić, L., Ilić, M., Tabain, I., Bogdanić, M., Grgić, I., Gorenec, L. & Savić, V. (2021) Immunological markers in neuroinvasive arboviral infections. U: Vilibić-Čavlek, T., Barbić, L., Savić, V., Tabain, I. & Kaić, B. (ur.)(Re-)emergentni arbovirusi u sjeni pandemije COVID-19 : program i knjiga sažetaka.
@article{article, author = {\v{Z}idovec Lepej, Snje\v{z}ana and Barbi\'{c}, Ljubo and Sabadi, Dario and Peri\'{c}, Ljiljana and Ili\'{c}, Maja and Tabain, Irena and Bogdani\'{c}, Maja and Grgi\'{c}, Ivana and Gorenec, Lana and Savi\'{c}, Vladimir and Poto\v{c}nik-Hunjadi, Tanja and Stevanovi\'{c}, Vladimir and Dvorski, Elizabeta and Butigan, Tamara and Kolaric-Sviben, Gordana and Vilibi\'{c}-\v{C}avlek, Tatjana}, year = {2021}, pages = {34-35}, keywords = {immunological markers, tick-borne encephalitis virus, West Nile virus, Toscana virus}, isbn = {978-953-8362-10-1}, title = {Immunological markers in neuroinvasive arboviral infections}, keyword = {immunological markers, tick-borne encephalitis virus, West Nile virus, Toscana virus}, publisherplace = {Zagreb, Hrvatska} }
@article{article, author = {\v{Z}idovec Lepej, Snje\v{z}ana and Barbi\'{c}, Ljubo and Sabadi, Dario and Peri\'{c}, Ljiljana and Ili\'{c}, Maja and Tabain, Irena and Bogdani\'{c}, Maja and Grgi\'{c}, Ivana and Gorenec, Lana and Savi\'{c}, Vladimir and Poto\v{c}nik-Hunjadi, Tanja and Stevanovi\'{c}, Vladimir and Dvorski, Elizabeta and Butigan, Tamara and Kolaric-Sviben, Gordana and Vilibi\'{c}-\v{C}avlek, Tatjana}, year = {2021}, pages = {34-35}, keywords = {immunological markers, tick-borne encephalitis virus, West Nile virus, Toscana virus}, isbn = {978-953-8362-10-1}, title = {Immunological markers in neuroinvasive arboviral infections}, keyword = {immunological markers, tick-borne encephalitis virus, West Nile virus, Toscana virus}, publisherplace = {Zagreb, Hrvatska} }




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