Naslov
Intracerebroventricular administration of betacytotoxics alters expression of brain monoamine transporter genes

Autori
Šalković-Petrišić, Melita ; Lacković, Zdravko

Izvornik
Journal of neural transmission (0300-9564) 110 (2003), 1; 15-29

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
alloxan; streptozotocin; monoamine transporter; brain

Sažetak
Intracerebroventricular (icv) administration of betacytotoxics alters brain monoamine neurotransmission, without producing hyperglycemia. By means of in situ hybridization, we have investigated the expression of dopamine, noradrenaline and serotonin transporter (DAT, NAT, 5-HTT, respectively) mRNAs, in the brain of alloxan- and streptozotocin-icv treated rats. We found alterations of all three monoamine transporter genes expression in various brain raegions. Alterations were region-specific, monoamine-specific and related to the duration of diabetes. Changes may suggest altered response to antidepressants in streptozotocin-icv treated rats, used as an animal model of sporadic Alzheimer's disease.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA