Naslov
EFFECTS OF CHANGES IN GLYCOLIPID CELL MEMBRANE COMPOSITION ON THE COMPOSITION OF LIPID RAFTS IN SH-SY5Y HUMAN NEUROBLASTOMA CELL LINE

Autori
Milorad Zjalić

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, doktorska disertacija

Fakultet
Medicinski fakultet u Osijeku

Mjesto
Osijek

Datum
20.07

Godina
2021

Stranica
188

Mentor
Prof.dr.sc. Marija Heffer dr.med ; prof.dr.sc. Marianna Pap dr.med.

Ključne riječi
SH-SY5Y ; miglustat ; conduritol B epoksid ; inzulin ; neuroplastičnost
(SH-SY5Y ; miglustat ; conduritol B epoxide ; insulin ; neuroplasticity)

Sažetak
Interfering with glycolipid biosynthesis caused dose-dependent cell death and change in morphology. Miglustat caused expected morphology changes in the form of neurite elongation, whilst CBE in sub-effective concentrations had the reverse effect on cell morphology. The insulin signaling pathway was upregulated with all treatments. Cells demonstrated changes in neuroplasticity and different responses to induced metabolic stress depending on which inhibitor was applied.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA