Naslov
The ionic substituted octacalcium phosphate for biomedical applications: A new pathway to follow?

Autori
Ressler, Antonia ; Ivanišević, Irena ; Žužić, Andreja ; Somers, Nicolas

Izvornik
Ceramics international (0272-8842) 48 (2022), 7; 8838-8851

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
bone regeneration ; bone scaffolds ; calcium phosphates ; ionic substitution ; octacalcium phosphate ; osteogenesis

Sažetak
Numerous studies have found that octacalcium phosphate possesses promising biological properties applicable to bone tissue regeneration. To further improve the osteogenic and regenerative properties of octacalcium phosphate, substitutions with Sr2+, Zn2+, Mg2+, Fe3+, Na+, F− and CO32− ions have been investigated in recent years. Despite that, hydroxyapatite is still considered the most promising calcium phosphate for bioactive bone grafts due to its biocompatibility, physicochemical similarity to biological apatite, osteoconductivity and strong bonding with the surrounding tissue. However, better biological properties of octacalcium phosphate in vivo as well as a larger volume of regenerated bone tissue, compared to hydroxyapatite, were confirmed by many studies. This review summarizes recent and relevant studies on cationic and anionic substitutions in the crystal lattice of octacalcium phosphate and its in vitro biological performance. It also discusses future challenges and prospects for the use of substituted octacalacium phosphate.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Kemijsko inženjerstvo, Temeljne tehničke znanosti

POVEZANOST RADA