Naslov
Važnost DISC1 proteina u procesu neurorazvoja
(DISC1 as an important protein involved in the process of neurodevelopment)

Autori
Marion, Carla

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, diplomski rad, preddiplomski

Fakultet
Odjel za biotehnologiju

Mjesto
Rijeka

Datum
16.07

Godina
2019

Stranica
31

Mentor
Bradshaw, Nicholas James

Ključne riječi
DISC1 ; neurorazvoj, shizofrenija ; proteinske interakcije
(DISC1 ; neurodevelopment, schizophrenia ; protein-protein interactions)

Sažetak
The Disrupted In Schizophrenia 1 (DISC1) is an important protein involved in many biological pathways that define the process of neurodevelopment. Having originally been identified as a gene disrupted by a chromosomal translocation that segregated with major mental illness, many biological studies have since indicated DISC1 as one of the highest profile risk factors for schizophrenia and other related illnesses. DISC1 is found at the nucleus, the mitochondria and cytoskeleton-associated structures, as the centrosome. It displays a pleiotropic character with many suggested functions, subcellular locations and a broad range of interacting partners, majority of which take part in signaling pathways and processes that affect higher neurodevelopmental brain functions as well, such as neuronal migration, neuronal cell proliferation or adult neurogenesis. Major DISC1 binding partners involved in these processes include nuclear distribution protein nude-like 1 (NDEL1), nuclear distribution protein nude homolog 1 (NDE1), lissencephaly protein 1 (LIS1), pericentriolar material 1 (PCM1) and glycogen synthase kinase 3β (GSK3β). This supports a neurodevelopmental hypothesis to underlie the psychopathology of these disorders, proposing that a brain defect is inherited or sustained early in life, but is not fully expressed until adolescence. Together these findings suggest that schizophrenia and related illnesses may represent the end point of multiple different pathogenic pathways.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija

POVEZANOST RADA