Naslov
Influence of dietary white button mushrooms (Agaricus bisporus) on the kinetics of changes in the proportion of peripheral blood CD4+CD8 2 + T lymphocytes in lambs

Autori
Špoljarić, Branimira ; Shek Vugrovečki, Ana ; Mihelić, Damir ; Žura Žaja, Ivona ; Vince, Silvijo, Špoljarić, Daniel ; Živković, Mario ; Kardum Paro, Marijana Mirjana ; Vlahović, Ksenija ; Samardžija, Marko ; Vijtiuk, Nada ; Popović Maja

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Veterinarski arhiv (2022)

Status rada
Prihvaćen

Ključne riječi
immunostimulation, double-positive T cells, growth, diarrhea, sheep

Sažetak
The primary focus of the current study was to determine the potential benefits of supplementing sheep diet with white button mushrooms (WBM) in terms of growth, health and the kinetics of systemic CD4+CD8+ memory T lymphocytes in lambs. Forty-five female lambs (Lika breed) were divided into three groups: A - control group fed on free-range pasture during 222 days of the experiment, while groups B and C were housed in a separate facility for 42 days and fed either commercial feed mixture (FM) or FM supplemented with 15% of freshly prepared WBM, espectively, and ad libitum forage. For the remaining 180 days of the experiment, both groups (B and C) of lambs were kept free-range and fed pasture only. The lambs were monitored daily starting at Day 0 (or 90 days of age) before the treatments, weighed 30 and blood sampled on Days 0, 21, 42 and 222, and were clinically observed for incidence/severity of diarrhea and/or other signs of disease. In addition to morbidity, mortality was monitored too, and dead lambs were examined for gross pathology changes. The lambs fed FM supplemented with WBM (group C) had significantly higher body weight gain (P<0.05) at Days 42 and 222. They were neither diarrheic nor had any mortality cases throughout the experiment. Also, these lambs had a significantly increased (P< 0.05) proportion of CD4+ CD8+ T cells at Days 42 and 222. The obtained data supported our assumption on the efficacy of dietary WBM in immunostimulation of CD4+CD8+ memory T lymphocytes in lambs, resulting in protection against on-farm diarrhea and increased growth rate.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

POVEZANOST RADA